ADDICTION

This study tests whether a long-term, high-dose prescription stimulant (lisdexamfetamine) can help people with moderate to severe methamphetamine use disorder stay in treatment and reduce use. About 80 participants will receive either the drug or a placebo alongside standard care…

This study tests whether adding a high-dose stimulant medication and a rewards program (contingency management) to usual care helps adults reduce their methamphetamine use. 440 participants will be randomly assigned to one of four groups for 15 weeks. The goal is to see which com…

This study tests whether semaglutide, a drug used for diabetes, can help people with alcohol use disorder drink less. About 80 adults will receive either the drug or a placebo shot weekly for 5 months. Researchers will measure changes in drinking, brain activity, and cravings usi…

This study looks at whether having motivational conversations every two weeks for four months after leaving the hospital can help people with alcohol use disorder stay sober longer. About 104 adults who completed alcohol withdrawal in the hospital will be split into two groups: o…

This study tests whether pairing a gentle electrical brain stimulation (tDCS) with computer-based cognitive training can help people with alcohol use disorder stay abstinent longer. About 40 participants who are already sober and in a residential program will receive the combined…

This pilot study tests a personalized brain stimulation treatment for people with severe addiction who haven't been helped by other treatments. Ten participants will first undergo detox, then have temporary electrodes placed in their brain to map addiction-related areas, followed…

This study tests a new way to prevent HIV among people who inject drugs and their friends. Researchers will train some participants to become peer educators, teaching their social network about HIV testing, PrEP (a daily pill that prevents HIV), and treatment for opioid use. The …

This study tests whether a non-invasive brain stimulation technique called tDCS can help people who vape nicotine daily to cut back. Forty adults aged 18-65 who vape regularly will receive either real or fake tDCS for 10 sessions over two weeks. Researchers will measure changes i…

This study is testing whether a 12-week therapy program called ECCCLORE is practical and acceptable for people who have both post-traumatic stress disorder (PTSD) and addiction. The program combines skills for managing emotions, stress, and relationships. Researchers will enroll …

This study looks at whether analyzing the weekly written stories of people in rehab for drug or alcohol addiction can help track their emotional and mental progress. About 35 adult men in a residential treatment center in Mexico will write about their feelings and challenges, and…

This study compares 60 adults aged 18-45 who are either addicted to smartphones, play video games for long periods, or have neither habit. Researchers will measure pain, posture, hand strength, and coordination to see how screen time affects the body. The goal is to understand th…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs alter brain information processing. Researchers will use brain scans, computer tasks, and interviews to measure changes in perception, belief flexibility, and electrical activ…

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with alcohol use disorder and healthy volunteers. Participants will complete tasks either inside or outside an MRI scanner to see how the brain works. The goal is to d…

This study looks at whether brain activity related to learning can predict how well teens (ages 14-17) respond to a program aimed at reducing cannabis use. Participants get a brain scan, then attend 10 weekly virtual sessions where they report their cannabis use and take drug tes…

This study follows 10,000 people seeking help for substance or behavioral addictions. Researchers will track their medical, brain, social, and mental health over several years using interviews and tests. The goal is to learn what leads to better outcomes, not to test a new treatm…