Acute respiratory distress syndrome (ARDS)

This study tests an experimental drug called centhaquine in 80 adults with moderate to severe ARDS, a life-threatening lung condition. The drug is added to standard care to see if it improves oxygen levels and reduces deaths. Participants must be in the ICU and start treatment wi…

This trial tests whether using electrical impedance tomography (EIT) to guide ventilator pressure settings improves lung function in patients with moderate-to-severe acute respiratory distress syndrome (ARDS) who are placed face down (prone positioning). Researchers will compare …

This study tests whether a traditional Chinese herbal formula, Xuanbai Shengmai Decoction, can improve survival in adults with acute respiratory distress syndrome (ARDS), a severe lung condition often seen in the ICU. About 308 participants will receive either the herbal decoctio…

This study tests a new way to use breathing machines for people with severe lung failure (ARDS). The goal is to reduce lung damage by using very gentle breaths and adding a machine that helps remove carbon dioxide from the blood. About 290 adults on breathing machines for less th…

This study looks at whether lying on the side at different angles can improve lung function in people with acute respiratory distress syndrome (ARDS), a serious lung condition. About 140 adult patients will be randomly placed in either the standard face-down position or a side-ly…

This study looks at whether the force of mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) can damage the brain. Researchers will measure a protein called S100B in the blood, which is a sign of brain injury, and track thinking and memory problems …

This study looks at two bedside methods to measure how much of the lung can be reopened in patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. It also compares four different ways to set the ventilator's positive end-expiratory pressure (PEEP). The g…

This study looks at whether the recruitment-to-inflation ratio (R/I ratio), a measurement used to guide ventilator settings in patients with acute respiratory distress syndrome (ARDS), gives the same result when repeated in the same patient. Researchers will measure it twice in 8…

Hispanic patients are twice as likely to die from respiratory failure as non-Hispanic patients, partly due to deeper sedation and less physical therapy. This pilot study will test a 'safer sedation bundle'—a set of tools and practices to help ICU staff follow guidelines more clos…

This study will compare two non-invasive breathing support methods—a face mask that pushes air in and a special nasal tube that delivers high-flow oxygen—for adults in the emergency room with dangerously low blood oxygen. About 500 participants will be randomly assigned to one me…

This study will observe 40 adults with acute respiratory distress syndrome (ARDS) on ventilators. Researchers will adjust the ventilator's pressure settings and use ultrasound to measure vein congestion, checking if certain settings are linked to better kidney outcomes. The goal …

This pilot study will enroll 80 ICU patients with acute hypoxemic respiratory failure to compare two ventilator strategies: one that allows patients to breathe spontaneously and one that fully controls their breathing. The goal is to see if a larger trial is possible and to gathe…

This study looks at how different levels of breathing support (PEEP) affect blood flow congestion in the veins of patients with acute respiratory distress syndrome (ARDS). Researchers will use ultrasound to grade congestion in the liver, kidney, and portal veins as absent, modera…

This observational study will analyze blood and sputum samples from 411 adults with acute respiratory distress syndrome (ARDS) who are on ventilators. Researchers will look for patterns in microbes, metabolites, and gene activity to see if they can predict how well patients respo…

This study will follow 800 adults with acute respiratory distress syndrome (ARDS) in a Korean hospital to learn about their symptoms, treatments, and outcomes. Researchers will collect data from medical records and monitor how different ventilator settings affect recovery. The go…