Thyroid gland papillary carcinoma

This study tests whether radiofrequency ablation (using heat) can safely cure small, low-risk thyroid cancers without surgery. Thirty adults who decline surgery or active monitoring will receive the treatment and be followed for a year. The goal is to see if the cancer is complet…

This study tests a device that uses nanosecond electrical pulses to destroy small papillary thyroid cancers (up to 1.5 cm) without cutting the skin. Fifteen participants will get the outpatient procedure under local anesthesia. The main goal is to check safety and side effects, n…

This study tests whether freezing thyroid tumors with a probe (cryoablation) can safely shrink or eliminate them. It includes people with small papillary thyroid cancers and those with benign nodules. Researchers will track tumor size changes over a year and compare results with …

This trial tests whether two approved drugs, dabrafenib and trametinib, can treat rare cancers that have a specific genetic change called BRAF V600. These drugs are already used for melanoma and lung cancer, but researchers want to see if they help people with other cancer types.…

This phase 2 trial tests a drug called XL092 in 33 people with advanced thyroid cancer that has stopped responding to radioiodine therapy. XL092 works by blocking a protein that helps cancer cells grow. The study aims to see if the drug can slow or stop cancer progression.

This study compares two treatments for low-risk papillary thyroid cancer: standard surgery and a less invasive option called ultrasound-guided thermal ablation, which uses heat (radiofrequency, microwave, or laser) to destroy tumors. Researchers will track about 3,700 patients ag…

This study tests whether a smaller, more targeted neck surgery (selective neck dissection) works as well as the standard larger surgery (modified neck dissection) for people with papillary thyroid cancer that has spread to only 1 or 2 small lymph nodes in the side of the neck. Ab…

This phase 2 trial tests whether two targeted drugs, vemurafenib and cobimetinib, can make thyroid cancer cells more responsive to radioactive iodine therapy. The study enrolls 21 adults with high-risk, BRAF-mutated thyroid cancer who have not yet received radioactive iodine. Par…

This early-stage trial tests a new radioactive drug called Af-001 in people with advanced differentiated thyroid cancer that cannot be removed by surgery or has spread. The study has two parts: first, to find the safest dose, and second, to see if multiple doses can shrink tumors…

This study compares two surgical approaches for papillary thyroid cancer that has spread to lymph nodes in the neck: robotic surgery through the armpit versus traditional open surgery. The goal is to see if the robotic method offers similar cancer control and survival rates while…

This trial is testing two drugs, vemurafenib and cobimetinib, already approved for melanoma, in adults with other rare cancers that have a specific genetic change called BRAF V600 mutation. The goal is to see if the combination can shrink tumors or stop them from growing. About 3…

This study tests whether giving targeted drugs before radioactive iodine (RAI) can make thyroid cancer tumors absorb more RAI, potentially improving treatment. It includes 32 children and teens with metastatic differentiated thyroid cancer that has spread to the lungs. Researcher…

This study is testing a new type of PET/CT scan (18F-TFB) to see if it can find thyroid cancer that has come back or spread better than the current standard scan. About 24 adults with papillary or follicular thyroid cancer will get both scans to compare results. The goal is to im…

This study looks at whether a special type of ultrasound (contrast-enhanced ultrasound) can predict how much cancer has spread to lymph nodes in patients with early-stage thyroid cancer. Researchers will review past images from 600 patients and compare them to surgical results. I…

This study tracks 50 people who choose radiofrequency ablation (RFA) for benign thyroid nodules or low-risk papillary thyroid cancer instead of surgery. Researchers will monitor long-term outcomes and quality of life using questionnaires. The goal is to see if RFA is a good alter…

This study tests whether human-centered nursing care delivered through WeChat can lower emotional distress and improve quality of life for people who are awake during a minimally invasive thyroid cancer treatment called thermal ablation. About 108 adults with papillary thyroid ca…

This study tests if health and wellness coaching helps people with papillary or follicular thyroid cancer follow their treatment plans and live healthier lives. Twenty adults who have had their thyroid removed and take daily thyroid medication will work with a coach to set goals …

This study is for people who have or might have a thyroid nodule or thyroid cancer. Researchers want to learn more about how to diagnose and treat these conditions. Participants will have standard medical tests like blood draws and scans, plus some extra research tests. The goal …

This study aims to create and test a scoring system called RTAS to evaluate how well surgeons perform robotic thyroidectomy, a surgery to remove all or part of the thyroid gland. Researchers will observe 200 participants with thyroid cancer or benign nodules who are having this s…

This study looks at whether a fine needle biopsy (a small sample taken with a thin needle) gives the same molecular classification results as a larger surgical sample in people with papillary thyroid cancer. About 130 adults with confirmed or suspected thyroid cancer will provide…