Thrombocytopenia

Researchers test whether giving low-dose rituximab after an initial treatment can make the response last longer in adults with immune thrombocytopenia (ITP), a condition where the immune system attacks platelets. The trial enrolls adults whose ITP has not responded well to steroi…

This study tests a drug called herombopag in people with chronic liver disease who have low platelet counts and need surgery. The goal is to see if the drug can safely raise platelet levels enough to reduce bleeding risk during the procedure. About 101 adults with mild to moderat…

This study looked at whether the drug avatrombopag can safely and effectively raise platelet counts in people who develop dangerously low platelets after a liver transplant. Researchers compared 67 patients who received the drug with 67 similar patients who got standard care. The…

This trial tests whether rifaximin, an antibiotic that works in the gut, can improve low platelet counts in people with hepatitis C-related cirrhosis. Low platelets are common in cirrhosis and can raise the risk of serious bleeding. Researchers will give 165 participants either r…

This study tests whether a 5-day course of avatricopal can safely raise platelet counts in people with chronic liver disease who have low platelets and need surgery. The goal is to see if more patients reach a platelet count of at least 50×10⁹/L on the day of their procedure, whi…

This early-phase trial tests a new cell therapy called MegaLT for people with dangerously low platelet counts that don't improve after radiation, chemotherapy, or stem cell transplant. Only 10 participants will receive the injection at different doses to check safety and how the …

This study tests whether a low daily dose of the antibiotic linezolid, added to a personalized combination of other drugs, is safe and tolerable for people with multidrug-resistant tuberculosis (MDR-TB). Participants take either linezolid or a placebo for 16 weeks, alongside thei…

This study looked at whether giving romiplostim, a drug that boosts platelet production, could reduce the need for platelet transfusions in patients with low platelet counts after heart or lung transplantation or use of heart/lung support devices. Researchers compared a group of …

This study tested the drug eltrombopag in 34 people with moderate aplastic anemia, a condition where the bone marrow doesn't make enough blood cells. Eltrombopag is a pill that mimics a natural protein to stimulate blood cell production. Researchers measured whether it safely imp…

This phase 2 study tested whether the drug romiplostim can prevent severe low platelet counts caused by chemotherapy in people with lymphoma. Eleven adult patients received weekly injections of romiplostim during their 21-day chemo cycles. The goal was to see if it could reduce t…

This early-stage trial tested a new drug called PN20 in 24 adults with lymphoma or solid tumors who were getting chemotherapy. The goal was to see if a single injection before chemo could safely prevent a drop in platelets, which can cause bleeding. Researchers checked safety and…

This phase 2 trial tested the drug sirolimus (rapamycin) in 61 children and young adults with complicated vascular anomalies—abnormal blood vessel growths that can cause pain, bleeding, or organ problems. The goal was to see if sirolimus could safely shrink these anomalies and im…

This study tested a drug called eltrombopag in 118 people with bone marrow failure who had a stem cell transplant. The goal was to see if the drug could help their platelet levels recover faster after the transplant. Platelets are blood cells that help stop bleeding, and slow rec…

This study tested a doctor-designed dose adjustment algorithm to prevent unplanned delays in FOLFOX chemotherapy for people with cancers of the colon, stomach, esophagus, and other digestive organs. 52 adults participated, and the goal was to see if the algorithm could keep treat…

This study looked at 68 people with low platelet counts who had become resistant to platelet transfusions due to HLA antibodies. Researchers tested a new lab method (C1q binding) on stored blood samples to see if it could better predict whether a transfusion would work compared t…

This study looks back at medical records of people who had an allogeneic stem cell transplant to see whether romiplostim helped their platelets recover faster. Platelets are blood cells that help clotting, and low counts are common after transplant. The researchers will compare p…

This completed study looked at blood samples from 70 children and adults newly diagnosed with immune thrombocytopenic purpura (ITP), a condition that causes easy bruising and bleeding. Researchers wanted to see if certain immune and blood markers could predict whether the disease…

This study looked at whether it is safe to lower the number of platelets needed before placing a central line (a special IV) in patients with blood disorders. Normally, patients get a platelet transfusion if their count is below 50, but this study tested a lower trigger of 10. Th…

This completed study observed 72 pregnant women with HELLP syndrome in the ICU. Researchers tracked daily changes in platelets, liver enzymes, and lactate dehydrogenase before and after delivery. The goal was to understand how these biological markers evolve, not to test a treatm…

This study tested whether a blood test called thromboelastography (TEG) can better guide blood-thinning treatment in 61 patients on ECMO life support. ECMO patients face serious risks from bleeding or clotting, and current monitoring methods are not very reliable. Researchers com…

This study looked at 50 adults with severe low platelet counts who needed platelet transfusions. Researchers wanted to understand why some patients stop responding to these life-saving transfusions. They focused on antibodies that attack the donor platelets, aiming to find better…

This completed Phase 2 study looked at 244 glioblastoma patients to see if platelet counts during radiation and chemotherapy could predict who would develop dangerously low platelets later. The goal was to create a monitoring plan for high-risk patients. No new drug or treatment …

This study checked whether a generic eltrombopag olamine tablet works the same as the brand-name version in 36 healthy Chinese adults after a meal. Participants took a single dose of each formulation in random order, and researchers measured how the drug moved through their bodie…

This study looked at data from over 1000 preterm babies with low platelet counts to build a model that predicts their risk of major bleeding or death. The goal is to help doctors decide when a platelet transfusion is truly needed, since current guidelines based only on platelet c…

This study collected one blood sample from 40 adults with very low platelets (30,000 or fewer per microliter) due to blood cancers or their treatments. The goal was simply to gather samples for research, not to test any new drug or therapy. Participants had to be 18 or older and …