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New blood test may reduce bleeding and clotting in life support patients

NCT ID NCT04268940

Knowledge-focused Sponsor: Damian Ratano Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a blood test called thromboelastography (TEG) can better guide blood-thinning treatment in 61 patients on ECMO life support. ECMO patients face serious risks from bleeding or clotting, and current monitoring methods are not very reliable. Researchers compared TEG results with standard tests to see if TEG could identify patients at higher risk for these complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to better, safer ways to manage blood thinning and clotting in ECMO patients, potentially reducing complications.
What could go wrong
This is a small observational study, not a treatment trial. It only looks for correlations, so it cannot prove that using TEG improves outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

61 people

The number who actually took part.

Started

Jun 2020

Finished

Jun 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients suffering from cardiorespiratory failure and needing Extracorporeal Membrane Oxygenation

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Consecutive patients admitted in Toronto General Hospital Medical Surgical ICU (MSICU) supported with ECMO. Patients cannulated before admission (ECMO retrieval) can also be included Exclusion Criteria: * Refusal of consent, unavailability or impossibility to process blood samples before ECMO cannulation

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Conditions

The condition(s) this trial relates to.

thrombocytopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Extracorporeal circulation of blood; thrombocytopenia

Contacts and locations

Locations

  • University Health Network

    Toronto, Ontario, M5G2N2, Canada