Temporomandibular joint dysfunction syndrome
MONDO:0021895A common disorder noted with jaw movement. It may be caused by malocclusion, repetitive use injury, trauma or arthritis. It is more prevalent among females between their second and fourth decades. Clinical signs include preauricular pain, temporomandibular joint clicking (as the mandibular condyle slips from the articulation made with the capsular disk and temporal bone) and restriction of jaw motion. Clinical course is typically benign but may progress to associated headaches, ear and neck pain, tinnitus and dislocation of temporomandibular joint. Prognosis is favorable as a majority of cases will respond to conservative management.
Also known as: temporomandibular joint dysfunction syndrome, Costen Syndrome, Costen's Syndrome, Costen's complex, Costen's syndrome, Costens Syndrome, Joint Syndrome, Temporomandibular, Mandibular dysfunction
108 clinical trials for this condition and its sub-types, 85 tagged with Temporomandibular joint dysfunction syndrome itself.
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Can a dental compass cut radiation and improve TMJ splints?
Disease control Recruiting nowThis trial tests whether a dental compass and its software can create more accurate therapeutic splints for people with temporomandibular joint (TMJ) dysfunction and pain. It compares a group using this 3D-guided method to a group using manual fabrication, looking at the number o…
Sponsor: Dr. Dean Reeves Clinic • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Which surgery unlocks a locked jaw? a Head-to-Head test
Disease control Recruiting nowThis trial compares two surgical techniques for treating a painful jaw condition called disc displacement without reduction, where the jaw's cushioning disc slips out of place and limits mouth opening. Participants will receive either arthroscopic lysis and lavage, a procedure th…
Sponsor: Karolinska Institutet • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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Could your own bone marrow fix jaw pain? new trial tests it
Disease control Recruiting nowThis phase 3 trial tests whether injecting a concentrate of your own bone marrow (BMAC) into the jaw joint during arthroscopy reduces pain and damage better than a standard steroid shot. Twenty adults with long-lasting TMJ pain will be randomly assigned to one of the two treatmen…
Phase 3 • Sponsor: Weill Medical College of Cornell University • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Jaw joint relief: could a natural protein mix beat standard care?
Disease control Recruiting nowThis study tests whether injecting a mixture of hyaluronic acid and I-PRF (a concentrate of healing factors from your own blood) into the jaw joint, after a cleaning procedure called arthrocentesis, can reduce pain and improve jaw movement in people with a displaced disc. Partici…
Sponsor: Mansoura University • Aim: Disease control
Last updated Jul 16, 2026 00:00 UTC
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Could a special MRI replace dental X-Rays for jaw and tooth issues?
Diagnosis Recruiting nowThis study aims to see if a special MRI designed for teeth can diagnose jaw joint disorders, tooth infections, and help plan dental implants as well as or better than traditional X-rays. About 470 adults needing dental imaging will get both an MRI and standard X-rays, and the res…
Sponsor: University of Aarhus • Aim: Diagnosis
Last updated Jun 27, 2026 12:29 UTC
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New injection could ease jaw pain better than standard treatment
Symptom relief Recruiting nowThis study compares a new injection of liquid phase concentrated growth factor (LPCGF) to standard arthrocentesis (joint washing) for people with painful jaw clicking and limited mouth opening due to a displaced disc. Thirty-two adults aged 18-45 with unilateral disc displacement…
Sponsor: Horus University • Aim: Symptom relief
Last updated Aug 19, 2026 00:00 UTC
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Could a few needles ease your jaw pain?
Symptom relief Recruiting nowThis study tests whether adding dry needling to standard physical therapy helps people with jaw pain (TMJ dysfunction). One hundred adults will either get standard rehab alone or rehab plus dry needling. Researchers will measure pain, jaw movement, and quality of life to see if t…
Sponsor: Palacky University • Aim: Symptom relief
Last updated Aug 13, 2026 00:00 UTC
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Laser zaps TMJ pain: new study tests quick relief
Symptom relief Recruiting nowThis study tests whether a special laser device (Erchonia EVRL) can temporarily ease chronic jaw pain caused by TMJ disorder. Researchers will compare the laser to a placebo in 64 adults who have had constant jaw pain for at least 3 months. The main goal is to see if more people …
Sponsor: Erchonia Corporation • Aim: Symptom relief
Last updated Jun 27, 2026 12:35 UTC
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Shock wave therapy could be new hope for jaw pain sufferers
Symptom relief Recruiting nowThis study tests whether focused shock wave therapy can reduce pain and improve jaw function in people with temporomandibular disorders (TMD) of muscular origin. One hundred adults with moderate to severe jaw pain for at least 3 months will receive either shock wave therapy or a …
Sponsor: University of Sao Paulo General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Can online physio ease jaw pain as well as In-Person sessions?
Symptom relief Recruiting nowThis study tests whether online or group physiotherapy can be as effective as individual in-person sessions for treating jaw muscle pain (TMD). About 90 adults with jaw muscle pain will be randomly assigned to one of three treatment formats. The goal is to find more accessible wa…
Sponsor: Semmelweis University • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Jaw pain relief: which physical therapy technique works best?
Symptom relief Recruiting nowThis study compares two common physical therapy techniques—Mulligan and Maitland mobilization—for treating temporomandibular joint (TMJ) dysfunction, which causes jaw pain and limited movement. Thirty adults with TMJ pain will be randomly assigned to one of the two techniques, co…
Sponsor: Foundation University Islamabad • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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Could a simple mouthguard silence your ringing ears?
Symptom relief Recruiting nowThis study tests whether a stabilizing occlusal splint (a type of mouthguard) can reduce tinnitus (ringing in the ears) in people who also have temporomandibular joint (TMJ) disorder. Researchers will compare the real splint to a placebo splint in 63 adults over 4 months, measuri…
Sponsor: University of Sao Paulo General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Emotional intelligence may hold key to chronic pain relief
Knowledge-focused Recruiting nowThis study looks at how emotional intelligence—the ability to understand and manage emotions—relates to chronic orofacial pain (pain in the face or mouth lasting over three months). Researchers will compare 88 adults with and without this pain using questionnaires about emotions,…
Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC