Substance withdrawal syndrome

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This trial tests a program called ROOTS that places substance use counselors and peer recovery specialists directly in rural schools. The goal is to see if this approach helps teens who are referred or seek help on their own to engage in treatment and reduce their substance use. …

This trial tests whether a program that offers incentives for continuing treatment can help pregnant and postpartum people with substance use disorder stay engaged in care. Participants receive screening for social needs and are randomly assigned to either usual care or a conting…

This trial tests whether adding a relational health enhanced parenting support (RHEP) program to standard family-focused peer recovery services helps parents with substance use disorders. The study compares outcomes like parenting satisfaction, treatment retention, and substance …

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This study tests whether a program called CourtConnect, where peer recovery specialists meet with people in courthouses, can increase substance use disorder treatment and reduce overdose and incarceration. The program provides information, referrals, and up to three months of fol…

This pilot study investigates whether adding Dialectical Behavior Therapy (DBT)-informed principles to standard short-term inpatient substance abuse treatment helps patients better manage emotions and reduce symptoms. About 70 adults in a 12-week program will either receive usual…

This study tests a new eight-session group therapy program for adults hospitalized with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and behavioral activation to help participants manage cravings and develop alternati…

This study tests whether a new four-session group program, called the First Step Program, can be delivered in hospital settings and help people with substance use disorders. The program combines motivational interviewing, acceptance and commitment therapy, and group support to bo…

This study will test an app called JomCare that sends personalized support to men who have sex with men when they are most likely to engage in chemsex (using drugs before or during sex). The goal is to reduce risky behaviors and prevent new HIV infections. About 482 HIV-negative …

This study will bring medication for addiction and cognitive behavioral therapy to homeless veterans living in VA supportive housing. The goal is to help them stay housed and reduce substance use. About 8,000 veterans across multiple VA sites will take part.

This study tests if adding a safe dye to a drink can prove that urine samples are real and not tampered with. About 114 adults with substance use disorder will drink Gatorade with or without the dye, then provide a urine sample 15 minutes later. Researchers will check for the dye…

Researchers at Karolinska Institutet are testing a digital self-help tool called Preventox for patients discharged from intensive care after an intoxication or overdose. The tool lets patients set goals, track substance use, identify high-risk situations, and make a crisis plan. …

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

Researchers are testing whether a handheld device that delivers mild electrical pulses to the ear can be used at home by adults receiving treatment for substance use disorder. Participants use the device for about 60 minutes a day for 30 days. The study measures whether people ca…

Alcohol withdrawal affects many hospitalized patients and standard sedative treatments have serious side effects. Researchers at the University of Colorado are testing whether intravenous sodium acetate, a natural byproduct of alcohol that the brain can use as fuel, is safe and p…

This study tests dexmedetomidine, a sedative that doesn't slow breathing, in 246 premature babies on ventilators. The goal is to see if it reduces the need for opioids, shortens time on the breathing machine, and improves long-term brain development. Babies will receive the drug …

This trial tests whether a brief therapy called Written Exposure in Substance Treatment (WEST) can reduce PTSD symptoms in people staying at a residential substance use program. Participants with PTSD are randomly assigned to receive WEST plus usual care or usual care alone. The …

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce alcohol withdrawal symptoms and cravings in people with moderate-to-severe alcohol use disorder. 105 adults will stay in a hospital for 5 days, receive either CBD or a placebo alongside standard care…

This trial tests whether Narrative Enhancement and Cognitive Therapy (NECT), a 12-session group program, can help adults with severe mental health disorders — including substance use disorders — overcome self-stigma and promote personal recovery. About 106 participants receiving …

This study tests a new 8-session group program designed to help people with substance use disorder better understand and regulate their emotions. About 20 adults receiving inpatient care at two hospitals in Korea will take part. The program combines motivational interviewing and …

This study tests whether equine-assisted therapy (working with horses) can improve mental health and reduce cravings in people recovering from addiction. Twenty-two adults who have completed detox will be randomly assigned to either receive 22 sessions of equine therapy over 24 w…

This study tests a new way to help people going through alcohol withdrawal feel less anxious. It combines hypnosis with aromatherapy, using a calming scent to trigger the relaxation learned during hypnosis. About 80 adults in a hospital addiction unit will either get this combine…

Researchers at the National Institute of Mental Health are studying how everyday feelings, like stress or frustration, influence decision-making. They will follow 420 adults aged 18 to 55, including healthy volunteers and people with varying levels of depression, anxiety, or addi…

Researchers in France ask whether adults treated for substance use disorder also depend more heavily on conversational AI tools. About 100 outpatients at specialized addiction centers fill out one 15-minute questionnaire covering their AI use and their DSM-5 substance use criteri…

This study looks at whether adding a clinical pharmacist to community mental health teams (called FACT teams) helps people with severe mental illness and substance use disorders feel better and manage their medications more effectively. About 160 adults will take part, and the st…

This study will observe 60 adults in residential therapeutic communities in Mexico to understand how recovery from substance use unfolds over time. Participants will answer quick mobile surveys several times a day about cravings, mood, and social interactions for 8 to 12 weeks. T…