Substance withdrawal syndrome
MONDO:0005567A substance-specific organic brain syndrome that follows the discontinuation of administration or use, or reduction in intake of a substance (including alcohol, prescribed medications and recreational drugs). Syndrome manifests with diverse, often painful physical and psychological symptoms, which include but not limited to intense drug craving, anxiety, depression, insomnia, nausea, perspiration, body aches, tremors, hallucinations, and convulsions.
Also known as: drug withdrawal, drug withdrawal syndrome, substance withdrawal, substance withdrawal disorder, substance withdrawal syndrome, withdrawal syndrome, withdrawal disorder
157 clinical trials for this condition and its sub-types, 30 tagged with Substance withdrawal syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Substance withdrawal syndrome
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Neonatal abstinence syndrome 18 trials
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Alcohol withdrawal 11 trials · 13 incl. sub-types
1 sub-type
- Alcohol withdrawal delirium 2 trials
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Baclofen withdrawal syndrome 0 trials
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Could a seizure drug curb alcohol withdrawal in trauma wards?
Disease control Stopped earlyThis trial tests whether valproate, a medication used for epilepsy, can help prevent or ease alcohol withdrawal symptoms in heavy drinkers admitted to trauma care. Participants receive standard treatment with lorazepam (a benzodiazepine) as needed, and some also get valproate. Th…
Phase 4 • Sponsor: CAMC Health System • Aim: Disease control
Last updated Aug 20, 2026 00:00 UTC
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New approach aims to boost HIV prevention in LGBTQ+ individuals struggling with addiction
Prevention Stopped earlyThis study tested a program to help HIV-negative transgender women and men who have sex with men who also have a substance use disorder stick with PrEP, a daily pill or shot that prevents HIV. Participants received counseling and text support, with extra help for those who strugg…
Sponsor: Friends Research Institute, Inc. • Aim: Prevention
Last updated Jun 27, 2026 09:04 UTC
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Ear stimulation device may tame alcohol withdrawal symptoms
Symptom relief Stopped earlyThis study tests whether a wearable device that sends tiny electrical pulses to the ear — a method called transcutaneous auricular neurostimulation (tAN) — can help people going through alcohol withdrawal. The device targets the vagus and trigeminal nerves, which may influence wi…
Sponsor: Erin Takemoto • Aim: Symptom relief
Last updated Aug 07, 2026 00:00 UTC
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Methadone tested to shorten time on breathing machines in ICU
Symptom relief Stopped earlyThis study tested whether giving methadone to ICU patients on breathing machines could help them get off the ventilator faster. Patients who needed strong painkillers were given either methadone or a placebo. The trial was stopped early and only included 9 people, so no firm conc…
Phase 4 • Sponsor: Henry Ford Health System • Aim: Symptom relief
Last updated Jun 27, 2026 08:02 UTC
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Can a restless legs drug ease opioid withdrawal?
Symptom relief Stopped earlyThis study tested whether pramipexole (Mirapex), a drug for restless legs syndrome, could also reduce symptoms of opioid withdrawal in people with opioid use disorder. The trial planned to enroll 75 adults but was terminated early. Researchers measured changes in restless legs se…
Phase 2/3 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC