Substance abuse

This trial tests whether valproate, a medication used for epilepsy, can help prevent or ease alcohol withdrawal symptoms in heavy drinkers admitted to trauma care. Participants receive standard treatment with lorazepam (a benzodiazepine) as needed, and some also get valproate. Th…

This study tests whether combining a gentle brain stimulation technique called tDCS with computer-based cognitive training can help people with stimulant or alcohol use disorders stay abstinent. Participants, who have already been abstinent for at least three weeks, will receive …

This phase 2 trial tested whether cannabidiol (CBD), a non-psychoactive compound from cannabis, could help people with alcohol use disorder reduce their drinking. The study also looked at whether CBD could protect the brain and liver from alcohol's harmful effects. Only 10 people…

This study tested whether a type of brain stimulation called intermittent theta burst stimulation (iTBS) could help people with alcohol use disorder reduce cravings and risky behavior during inpatient treatment. Only 2 people were enrolled before the trial was stopped early. The …

This phase 2 study tested a drug called TMP-301 in 110 adults with alcohol use disorder to see if it is safe and helps reduce drinking. Participants took TMP-301 or a placebo daily for 14 weeks. The trial was terminated early, so we don't have clear results on whether the drug wo…

This study tested a drug called acamprosate in adults with alcohol dependence who were part of a DUI court program. The goal was to see if the medication could help them stay sober and reduce cravings. Only 4 people enrolled before the study was stopped, so results are very limit…

This study tested educational videos for Hispanic/Latinx families with teens aged 15-17 to prevent opioid misuse and overdose. The program focused on safe storage, opioid knowledge, and changing attitudes. Only 6 families took part before the study ended early.

This study tested a program to help HIV-negative transgender women and men who have sex with men who also have a substance use disorder stick with PrEP, a daily pill or shot that prevents HIV. Participants received counseling and text support, with extra help for those who strugg…

Researchers at the University of Florida are testing whether computerized cognitive training can help people with alcohol use disorder improve their memory, self-control, and thinking skills during inpatient treatment. Participants complete up to 12 sessions of adaptive brain-tra…

This study tested whether a combination of non-opioid medicines (ketamine, ketorolac, and acetaminophen) can control pain after robotic prostatectomy as well as standard opioid painkillers. Men aged 40-75 with prostate cancer were randomly assigned to receive either opioids or th…

This study tested whether a specially designed video game could reduce alcohol-related problems like hangovers, blackouts, and risky sex in LGBTQ+ teens aged 14-18. The game was meant to teach safer drinking habits. The study was stopped early and only 28 people took part, so res…

This study tested a mindfulness-based mobile app designed specifically for young Black men (ages 18-29) to help them handle stress from racism and reduce alcohol or marijuana use. Participants used a self-guided app, some with real-time feedback, and reported their daily stress a…

This study looks at whether imagining positive future events (Episodic Future Thinking) and using low-intensity focused ultrasound on the brain can help people with both chronic pain and alcohol use disorder. Ten adults will try these interventions and report changes in pain, cra…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This study aimed to see if a short test called BEARNI could detect alcohol-related cognitive impairments (like memory and thinking problems) in people with alcoholic cirrhosis. The researchers planned to enroll patients with cirrhosis, but the study was stopped early after only o…

This study examined whether ride-sharing services like Uber and Lyft are linked to fewer alcohol- and drug-related car accidents and sexual assaults. Researchers collected data from trauma registries, transportation departments, and crisis centers in the Dallas area. The study wa…

This study tracked 239 adults in France taking baclofen for alcohol use disorder. Researchers called participants monthly for a year to see how many stopped the drug due to side effects. The goal was to better understand which side effects are caused by baclofen versus other fact…