Substance abuse

This study tests a harm reduction approach for people who use anabolic-androgenic steroids (AAS) without a prescription. Participants will receive four counseling sessions to help them reduce their steroid use and improve their health. The trial will measure changes in steroid us…

This early-phase trial tests a digital program called CONNECT, designed to help women who have survived sex trafficking access care for HIV, substance use, and mental health. Delivered through a street medicine team that serves unhoused women, the program pairs participants with …

This pilot study tests a behavioral program called CBITS-RTM, adapted for teens in juvenile detention. The program combines group and individual therapy to address post-traumatic stress and includes a module on racial trauma. Researchers want to see if it reduces PTSD symptoms an…

This study is developing and testing a smartphone app called METS4Vets, designed to help veterans with substance use disorders as they move from residential treatment back into everyday life. The app provides motivational and skills-building support. Researchers are enrolling 30 …

This study tests a program called CROSSROADS for adults who recently survived an opioid or stimulant overdose. It combines standard paramedic care with free legal help for issues like housing or benefits. Researchers want to see if this reduces drug use and contact with the crimi…

This study tests a mobile health app called mSYNC designed to help prevent HIV in people who use drugs and visit the emergency department. The app provides counseling and support for risk behaviors, mental health, and access to care. Researchers want to see if the app is acceptab…

This study tests whether a single session of Acceptance and Commitment Therapy (ACT) can help internally displaced adults manage stress and prevent substance use. Researchers will enroll 144 people who have been displaced by conflict and have used at least one substance (other th…

This study tests Project LYNX, a program that helps young adults (ages 18-29) who have recently been involved with the criminal legal system find and connect to substance use treatment and HIV-prevention services. The program pairs each participant with a trained peer navigator a…

This study tests a mobile app called PA-LINKS designed to help women who have recently been in jail or prison access HIV prevention medicine (PrEP) and treatment for opioid use disorder. About 74 women will use the app and work with a navigator to connect to these services. The g…

This study tests a mindfulness program called MINDS-UP to prevent substance use in children aged 10 to 14. About 45 kids will either take mindfulness classes plus a sports-based prevention program, or just the sports program alone. Researchers will check if the program is easy to…

This study tests whether a social network approach can encourage people who inject drugs to start HIV prevention medication (PrEP) and addiction treatment (MOUD). About 398 participants will be assigned to either the LINKED intervention or a control group. The goal is to see if p…

This study looks at ways to improve care for teens and young adults who have experienced sexual assault. The goal is to offer same-day HIV prevention medicine and substance use support during their emergency room visit. Researchers will work with young people to design and test t…

This trial tests a school-based program that combines classroom lessons with online modules to reduce the risk of vaping and prescription drug misuse in upper elementary students (ages 7-11). About 3,000 students from 30 schools will either receive the program or continue with st…

This study tests whether brief mindfulness and identity-affirming exercises can improve well-being and reduce mental health symptoms in LGBTQ youth aged 16-26 who are currently or recently unhoused. Two hundred participants will be randomly assigned to either the mindfulness prog…

This study tests whether brief, 1-2 minute videos featuring personal stories from other parents can reduce stigma and improve help-seeking among parents of children aged 6-18 with depression, ADHD, or substance use problems. Researchers will recruit 1,600 parents online and rando…

This study tests a smartphone app called Senyo Health for people with bipolar disorder who also struggle with alcohol or drug use. The app offers therapy, rewards for healthy behaviors, and weekly check-ins with a care manager. The goal is to see if the app is easy to use and hel…

This study tests an online platform called PURSUIT that teaches coping skills to Michigan youth aged 8-18 and their caregivers. The program provides cognitive-behavioral techniques for managing pain, stress, and mood, with extra substance use prevention content for teens 12 and o…

This study develops and pilot tests a written 'practice companion' designed to help clinicians and other trusted adults provide developmentally appropriate substance use care to youth ages 14 to 24. The companion offers practical guidance on cannabis, opioids, and other substance…

This pilot study will test a series of brief, private text messages sent via WhatsApp or Telegram to help people who use drugs in Kazakhstan feel more comfortable seeking PrEP, an HIV prevention pill. The messages address stigma, confidentiality worries, and misinformation. Forty…

This study aims to understand how people feel physically and mentally after they stop using drugs. Researchers will observe 120 adults aged 18-65 who have quit. The goal is to gather information, not to test a new treatment.

This study follows 600 offenders with both mental illness and substance abuse in Italy and California over three years. Researchers will compare community-based care in Italy with high-security hospitals in the US to see which model leads to better outcomes, like reduced violence…

This study looks at whether a special training program can help supportive housing agencies in New York and New Jersey use proven methods to prevent overdoses and improve tenant health. About 24 agencies and 2940 people will take part. The goal is to see how well agencies adopt t…

This study tests a computer alert that notifies doctors when a patient is about to move into a new phase of opioid therapy, such as from short-term to long-term use. The alert prompts doctors to review the patient's pain and goals, following CDC guidelines. Researchers will study…

This study tests whether a computer alert can help doctors identify and treat patients with opioid use disorder. About 200,000 adults will be involved, and doctors will either get an alert or not. The goal is to see if the alert increases the use of medications like buprenorphine…

This study tests a program called ADD'Pro that combines addiction treatment with personalized job counseling to help people with substance use disorders return to work. About 100 adults will be randomly assigned to either the ADD'Pro program or standard employment services. Resea…

This study tests whether a digital screening and brief intervention can help postpartum mothers reduce substance use. About 120 mothers enrolled in home visiting programs will complete online sessions and receive text messages. Researchers want to see which combination of digital…

This study looks at Link-Up, a new safe consumption room in Brussels where people can use drugs under medical supervision. Researchers will track 250 users to see if the service reduces risky behaviors like sharing needles or using in public. The goal is to understand how these r…

This study will compare obsessive-compulsive symptoms in 102 adults with substance use disorder to a similar group without it. Participants will complete interviews and questionnaires to measure OCD severity, addiction severity, and quality of life. The goal is to understand how …

This study will check if a simple frailty score (ISAR) can predict medication problems in elderly patients visiting the emergency department. Researchers will review the medical records of 300 patients aged 75 and older, looking for inappropriate prescriptions and dangerous drug …