Staphylococcal infection

This pilot study compares a new decolonization regimen using polyhexanide (nasal gel and body foam) to the standard mupirocin and chlorhexidine treatment for reducing Staphylococcus aureus bacteria before elective spine surgery. The trial includes 24 adults who carry Staph bacter…

This study tested whether a combination of topical antibiotics and antiseptic washes could reduce staph bacteria on the skin of Native American adults living on or near tribal lands. Participants were at high risk for staph infections due to diabetes, obesity, or recent infection…

This study tested a new medicine called AP-SA02, given through a vein, along with standard antibiotics for adults with a Staph blood infection. The main goal was to check if the combination is safe and tolerable. Researchers also looked at whether it helped clear the infection fa…

This study tested a lab-made antibody called 514G3 in 52 hospitalized adults with Staphylococcus aureus bloodstream infections. Participants received either a single dose of the antibody plus standard antibiotics or a placebo plus antibiotics. The main goals were to check safety …

This study compared two antibiotics, cloxacillin and cefazolin, in 315 adults with a serious bloodstream infection caused by methicillin-susceptible Staphylococcus aureus (MSSA). The goal was to see if cefazolin works as well as cloxacillin, the standard treatment, while potentia…

This completed trial tested a device that uses light to kill germs in the nose before surgery, aiming to prevent surgical site infections. Over 400 adults having major surgeries received either the light treatment or standard care. Researchers tracked infections and side effects …

This study tested a new way to prevent surgical site infections by using a special light treatment inside the nose just before surgery. Over 4,700 adults having major surgeries like heart, spine, or joint replacement took part. The goal was to see if this light therapy reduces in…

This study tested whether combining personal hygiene (using medicated washes and ointments) with household cleaning can prevent MRSA skin infections. Over 800 people from households with a recent MRSA infection took part. The goal was to see if this combined approach reduces the …

This completed study looked at 104 adults in the ICU with severe pneumonia caused by three common bacteria. Researchers checked whether the bacteria were sensitive to amoxicillin/clavulanic acid (AMC) or to third-generation cephalosporins (3GC), which are standard treatments. The…

This study compared staph bacteria from 57 patients with implant infections to 31 from healthy nasal carriers. Researchers looked at the bacteria's genes and ability to form biofilms (slimy coatings). The goal was to find what makes some staph strains more dangerous around implan…

This study looked at a new lab test called Antibiofilmogramme for people with diabetic foot infections caused by Staph bacteria. The goal was to see if the test could help doctors choose antibiotics that work better. 33 adults took part, and the study did not change their regular…

This study looked at how staphylococcus bacteria on the skin affect inflammation and immune responses in people with moderate to severe atopic dermatitis (eczema). Researchers took skin biopsies and blood samples from 41 adults to measure bacterial toxins and immune cell activity…

This study examined tissue samples from 50 patients with staphylococcal bone and joint infections to see if bacteria can hide inside human cells. Researchers used special staining to detect intracellular staphylococci and identify which cell types they occupy. The goal was to bet…

This lab study tested whether levobupivacaine, a local anesthetic used in patient-controlled analgesia (PCA) pumps, can kill Staphylococcus aureus bacteria. Researchers mixed the drug at two common concentrations with bacteria in a lab model and counted how many bacteria survived…

This study tested whether having a study team call doctors with a checklist could improve how they manage patients with Staphylococcus aureus bloodstream infections. The calls reminded doctors of key steps like follow-up blood cultures, proper antibiotics, and imaging tests. The …

This study looked at 278 diabetic patients to see if the same staph bacteria found in their noses also appear in their foot ulcers. Researchers compared the genetic fingerprints of the bacteria to understand the link. The goal was to learn more about infection risks, not to test …

This completed study tested a software platform called OR PathTrac that monitors bacteria in operating rooms. The goal was to see if giving hospitals feedback on where germs spread could help reduce surgical site infections. Over 800 adults having surgery took part. The study foc…

This completed study looked at 234 patients with severe staph pneumonia to see if a toxin called PVL makes the disease worse. Researchers compared survival rates between patients infected with PVL-producing bacteria and those without. They also collected blood samples to explore …