Sinusitis

Researchers are testing an experimental antibody drug called verekitug in adults with chronic rhinosinusitis with nasal polyps, a condition where inflamed tissue grows inside the nasal passages and causes congestion. Participants receive either verekitug or a placebo injection wh…

This study tests whether giving a probiotic (Saccharomyces boulardii) along with a common antibiotic can protect the gut bacteria of children aged 4 to 12 being treated for ear or sinus infections. The goal is to see if it reduces antibiotic-associated diarrhea and limits the spr…

This trial tests whether dupilumab, an injectable drug that blocks certain inflammatory signals, can reduce sinus swelling and improve symptoms like loss of smell and runny nose in adults with chronic sinusitis who do not have nasal polyps. Participants receive either dupilumab o…

This phase 3 trial tests whether Jinhua Qinggan Granules, a traditional Chinese herbal medicine, can eliminate symptoms of acute upper respiratory infections (like fever, sore throat, and congestion) within three days. About 273 adults with early-stage cold or flu will receive ei…

This trial tests whether two nasal pump sprays made from diluted seawater can safely ease symptoms of colds, rhinitis, sinusitis, and other upper respiratory infections. Participants, from 3 months old, will use one of the sprays for 7 days while doctors track symptom severity an…

This study looked at 52 adults with EGPA (a rare inflammatory disease) and severe chronic sinusitis with nasal polyps. They received mepolizumab 300 mg every 4 weeks. The goal was to see if the drug reduces polyp size and improves symptoms like nasal congestion and sense of smell…

This study tested two drugs, dexmedetomidine and nitroglycerin, to see which one better reduces bleeding during functional endoscopic sinus surgery (FESS). 66 adults having elective FESS were randomly assigned to receive one of the drugs to lower blood pressure and improve the su…

This study tested two different nasal packs used after nose surgery to see which one patients liked better and which led to better healing. Twenty adults who had nasal surgery received either a VELNEZ or NASOPORE pack. Researchers checked for pain, bleeding, and how well the pack…

This study tested a nitric oxide nasal spray against a saline placebo in 162 adults with recurrent acute sinusitis. Participants used the spray at the first sign of a new episode for two weeks. The goal was to see if the nitric oxide spray speeds up symptom relief and reduces the…

This small study tested a herbal tea made from berry and mango leaves in 10 adults with acute sinusitis. Participants drank the tea three times a day alongside their usual care for one month. Researchers measured changes in quality of life using a standard symptom questionnaire. …

This study looked at two methods to treat concha bullosa, a condition where the middle turbinate in the nose is enlarged and can block sinuses. 62 adults with chronic sinusitis were randomly assigned to have the turbinate crushed or partially removed during sinus surgery. After o…

This study tested whether Ectoin nasal spray helps relieve symptoms of acute sinusitis compared to another medication (Sinupret forte). 66 adults used the spray or took the other drug for 14 days. Doctors checked symptoms at day 7 and day 14, and patients kept a daily diary. The …

This Phase 2 study tested dupilumab (Dupixent) in 33 adults with chronic sinusitis but no nasal polyps. Participants received injections every two weeks for six months. The main goal was to see if the drug improves sinus symptoms and quality of life compared to a placebo.

This study tested whether adding the sedative drug dexmedetomidine to anesthesia improves the view for surgeons during endoscopic sinus surgery. Fifty adults with rhinosinusitis were enrolled. The goal was to see if the drug could make the surgical field clearer, potentially maki…

This small pilot study tested a new way to place dental implants in the upper jaw when there is not enough bone height. Surgeons used a special drill and a tiny camera to watch the sinus membrane during the procedure. The goal was to see how often the membrane gets torn, which ca…

This study tested a program to help doctors prescribe antibiotics more appropriately for common childhood infections like earaches, sore throats, and sinusitis. Over 1,000 doctors took part, receiving online training, personalized feedback on their prescribing habits, and support…