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Which drug keeps sinus surgery cleaner? dexmedetomidine vs. nitroglycerin

NCT ID NCT07585201

Symptom relief Sponsor: Zagazig University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two drugs, dexmedetomidine and nitroglycerin, to see which one better reduces bleeding during functional endoscopic sinus surgery (FESS). 66 adults having elective FESS were randomly assigned to receive one of the drugs to lower blood pressure and improve the surgeon's view. The main goal was to compare surgical field quality and drug costs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine and nitroglycerin
What this could lead to
If one drug works better, it could make sinus surgeries safer and cheaper by improving visibility and reducing bleeding.
What could go wrong
This is a small, completed study with only 66 participants, so results may not apply to everyone. Both drugs have side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

66 people

The number who actually took part.

Started

Sep 2022

Finished

Mar 2023

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Physical status: American Society of Anesthesiologists (ASA) I \& II. * Body Mass Index (BMI): 18.5-30 kg/m2. * Type of operation: elective bilateral FESS. * Type of anesthesia: general anesthesia. Exclusion Criteria: * Patients with known history of allergy to study drugs. * Anticipated difficult intubation. * Advanced hepatic, renal or cardiovascular diseases. * Central nervous system disorder, metabolic disease, and electrolyte imbalance. * Coagulopathies or taking drugs affecting coagulation.

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Conditions

The condition(s) this trial relates to.

Blood Loss, Surgical hypotensive disorder sinusitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Functional endoscopic sinus surgeries Hypotension Intraoperative bleeding

Contacts and locations

Locations

  • Zagazig university

    Zagazig, Sharqia Province, 44111, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.