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Rheumatic heart disease
MONDO:0006955An autoinflammatory condition following an infection with Group A Beta Hemolytic Streptococcus (GABHS), in which the heart is attacked by antibodies formed in reaction to a recent GABHS infection. Chief anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords, all of which can result in valvular dysfunction.
Also known as: RHD, disease, rheumatic heart, heart disease, rheumatic, rheumatic carditis
17 clinical trials for this condition and its sub-types, 17 tagged with Rheumatic heart disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Rheumatic heart disease
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Acute rheumatic heart disease 0 trials
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Rheumatic congestive heart failure 0 trials
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Rheumatic myocarditis 0 trials
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Rheumatic pericarditis 0 trials
1 sub-type
- Chronic rheumatic pericarditis 0 trials
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Can community hospitals in zambia master severe disease care?
Disease control Recruiting nowThis trial tests a new model of care called PEN-Plus, which brings specialized treatment for severe chronic diseases like diabetes, heart conditions, and sickle cell disease to first-level hospitals in Zambia. The goal is to train local health workers and set up clinics to manage…
Sponsor: Centre for Infectious Disease Research in Zambia • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Penicillin break: major trial tests if kids with mild RHD can ditch daily antibiotics
Disease control Recruiting nowThis Phase 3 trial will test whether children and teens with mild rheumatic heart disease (RHD) can safely stop taking long-term penicillin. About 922 participants aged 5-20 who have stable or normalized RHD after at least 2 years of antibiotics will be randomly assigned to eithe…
Phase 3 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Uganda program aims to stop heart disease in its tracks
Disease control Recruiting nowThis study looks at a program called ADUNU, which aims to find and treat people with rheumatic heart disease in two districts of Uganda. The program uses portable ultrasound to screen for the disease and a registry to keep patients on preventive medication. Researchers will check…
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Could a common ED drug help heart valve patients breathe easier?
Disease control Recruiting nowThis study tests whether sildenafil (the drug in Viagra) can help people with severe lung high blood pressure caused by long-term rheumatic heart valve disease. Researchers will give 100 participants either sildenafil or a placebo three times daily for six weeks. The main goal is…
Phase 2/3 • Sponsor: Sindh Institute of Cardiovascular Diseases • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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School nurses take on heart disease: 6,000 kids in prevention trial
Prevention Recruiting nowThis trial tests whether placing trained nurses in schools can prevent rheumatic heart disease in children aged 5 to 16 in Nepal and Zambia. The nurses will teach about the disease, check for strep throat, and help kids get antibiotics. The study will measure if this approach low…
Sponsor: Thomas Pilgrim • Aim: Prevention
Last updated Jun 27, 2026 08:13 UTC
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Shock waves for stiff heart valves: new balloon tested in First-in-Human trial
Symptom relief Recruiting nowResearchers are testing a new balloon device called SmartWave that uses shock waves to break up calcium in severely narrowed mitral valves. The study enrolls 10 adults with symptomatic mitral stenosis caused by mitral annular calcification or severely calcified rheumatic heart di…
Sponsor: Prince of Wales Hospital, Shatin, Hong Kong • Aim: Symptom relief
Last updated Sep 18, 2026 00:00 UTC