REM sleep behavior disorder

This study tests whether an oral drug called PXS-4728A can reduce brain inflammation in 40 adults aged 50-80 with isolated REM sleep behavior disorder (iRBD), a condition often leading to Parkinson's disease. Participants receive either the drug or a placebo for 12 weeks, and bra…

This study looks at whether terazosin, a drug usually used for high blood pressure, can slow the progression of Parkinson's disease. Researchers are tracking changes in heart and brain scans of 15 people who are either in early stages or at high risk for Parkinson's. The goal is …

This phase 2 trial tests whether carvedilol, a drug usually used for heart conditions, can slow the loss of dopamine transporters in the brain and delay Parkinson's symptoms. It follows 15 people with REM sleep behavior disorder and other early Parkinson's risk factors over three…

This study tests whether the drug idebenone can slow or prevent the progression of a sleep disorder called iRBD into Parkinson's disease or similar brain conditions. About 142 adults aged 40-75 with iRBD will receive either idebenone or a placebo for 5 years. Researchers will tra…

This study investigates whether a combination of skin biopsies, speech analysis, and ultra-high field 7T MRI can detect early signs of Parkinson's disease and dementia with Lewy bodies. It focuses on people with a specific type of REM sleep behavior disorder triggered by serotone…

This study tests whether a special heart scan using a radioactive drug called 123I-MIBG can help identify Lewy body disease, a type of dementia that also affects movement and sleep. Researchers will compare scan results with clinical diagnoses in 50 people who have conditions lik…

This study uses a special brain scan called DaTscan to look at how certain brain diseases affect the brain. Researchers will scan 500 adults with conditions like Parkinson's disease, dementia, mild cognitive impairment, or REM sleep behavior disorder. The goal is to see if DaTsca…

This study tests a new 'intelligent duvet' called Easy Sleep Monitoring (ESM) that uses built-in sensors to detect movement and estimate sleep. Researchers will compare its accuracy to standard sleep lab tests (video-polysomnography) in 50 people, including those with sleep disor…

This study tests whether a sleep health coaching program, based on cognitive behavioral therapy for insomnia, can improve sleep in firefighters who have trouble sleeping. About 400 firefighters from 20 fire agencies in Arizona will take part. Half will receive the coaching progra…

This study is testing whether a 6-month program of online exercise classes, guided meditation, and nutrition advice can improve thinking, sleep, and overall health in people with Parkinson's disease. 60 participants aged 40 to 85 will take part, with some starting the program rig…

This study investigates whether a combination of brain MRI scans, sleep recordings, and cognitive tests can track early brain changes in people with idiopathic REM sleep behavior disorder (iRBD), a condition that often precedes Parkinson's disease. Researchers will follow 50 peop…

This study explores whether the immune system plays a role in starting and driving Parkinson's disease. Researchers will collect blood, spinal fluid, stool, and saliva from people with REM sleep behavior disorder (a strong early sign of Parkinson's), people already diagnosed with…

This observational study follows people with early Parkinson's disease, those at genetic risk, and healthy volunteers over time. Researchers collect clinical exams, brain scans, and biological samples (blood, spinal fluid, skin, stool) to identify markers that predict how the dis…

This study looks at whether people with memory problems will wear and use digital devices like smartwatches, sleep headbands, and smartphone apps to collect health data. Researchers will combine this data with clinical information to build machine learning models that might one d…

This study enrolls 500 adults with a sleep condition called REM sleep behavior disorder (RBD), which often leads to Parkinson's disease or related brain disorders. Researchers will track symptoms like thinking, movement, and smell to develop a rating scale. The goal is to prepare…

This study looks at whether carvedilol, a drug used for heart failure, can reverse early heart changes seen in people with a sleep disorder that puts them at high risk for Parkinson's disease. Fifteen participants with REM sleep behavior disorder or reduced sense of smell will ta…

This study looks at whether terazosin, a drug used for high blood pressure, can change heart nerve activity in people at high risk for Parkinson's disease. Researchers are studying 15 adults with REM sleep behavior disorder (a strong early sign of Parkinson's) to see if the drug …

This study uses a small skin sample to measure levels of a protein linked to Parkinson's disease and REM sleep behavior disorder. Researchers will follow 100 participants for 18 months to see if changes in the protein match disease progression. The goal is to develop a simple bio…

This study looks at how problems with the body's internal clock (circadian rhythm) may contribute to REM sleep behavior disorder (RBD), a condition where people physically act out their dreams. Researchers will measure melatonin levels and sleep patterns in 30 adults recently dia…