REM sleep behavior disorder

MONDO:0005937

A disorder characterized by episodes of vigorous and often violent motor activity during rem sleep (sleep, rem). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393)

75 clinical trials for this condition and its sub-types, 48 tagged with REM sleep behavior disorder itself.

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↑ Sleep-wake disorder (1049)

Sub-types of REM sleep behavior disorder

Rapid eye movement sleep disorder 4 trials

Including sub-types (75) Tagged with REM sleep behavior disorder (48)

Trials to join now! 28 Not yet recruiting 9 Not yet finished but already full! 19 Completed 18 Terminated 1

Sleep drug tasimelteon tested for Dream-Acting disorder

Symptom relief Stopped early

This pilot study tested whether the sleep drug tasimelteon (Hetlioz) could reduce dream-enactment events in people with REM behavior disorder. Twenty participants took a nightly 20 mg capsule and tracked their symptoms in a daily diary. The study was terminated early, so results …

Early phase 1 • Sponsor: Brigham and Women's Hospital • Aim: Symptom relief

Last updated Jun 27, 2026 07:54 UTC

REM sleep behavior disorder

Where it sits in the disease tree

Sleep drug tasimelteon tested for Dream-Acting disorder