Could a new pill calm brain inflammation and slow Parkinson's-Linked sleep disorder?
NCT ID NCT05904717
First seen Jun 07, 2026 · Last updated Jun 18, 2026 · Updated 5 times
Summary
This study tests whether an oral drug called PXS-4728A can reduce brain inflammation in 40 adults aged 50-80 with isolated REM sleep behavior disorder (iRBD), a condition often leading to Parkinson's disease. Participants receive either the drug or a placebo for 12 weeks, and brain scans measure inflammation changes. The goal is to see if the drug is safe and can slow disease progression.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Clinical Neuroscience Nuffield Department of Clinical Neurosciences
Oxford, United Kingdom
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Cognitive Neuroscience Brain & Mind Centre
Camperdown, Sydney, 2050, Australia
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Parkinsons Disease Research Clinic - Macquarie University
Macquarie, New South Wales, 2109, Australia
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.