REM SLEEP BEHAVIOR DISORDER

This phase 2 trial is testing whether a 6-month program of online exercise classes, guided meditation, and nutrition guidance can improve thinking, sleep, and brain health in people with Parkinson's disease. Researchers will measure changes in cognition, inflammation, gut bacteri…

This study tests a behavioral (non-drug) treatment to reduce nightmares in adults with REM sleep behavior disorder (RBD). Participants attend 7 video sessions, with a family member joining 2 of them. The goal is to see if the therapy lowers nightmare frequency and severity.

This study follows 640 participants—including people with Parkinsonism, a sleep disorder called REM sleep behavior disorder, and healthy volunteers—for 5 years. Researchers use brain scans, movement tests, blood samples, and voice recordings to track how the disease changes over …

This observational study aims to see if people with REM sleep behavior disorder (RBD) have a higher rate of concussions or contact sports history compared to those without RBD. About 140 participants, aged 50 and older, will answer questions about past head injuries and sports. T…

This study looks at immune cells in the gut to understand how they might be involved in brain diseases like multiple sclerosis and Parkinson's. Researchers will collect tissue samples from 100 adults during colonoscopies. The goal is to learn more about the gut's role in these co…

This study aims to create a large national collection of blood and tissue samples from 230 people with Parkinson's disease or a related sleep disorder. Researchers will analyze the complete genetic code of participants and create stem cell lines to study how gene combinations con…

This study looks at how the brain changes over time in people with REM sleep behavior disorder, a condition that often leads to Parkinson's disease or similar disorders. Researchers will use brain scans and thinking tests to track these changes in about 86 adults. The goal is to …

This study follows 800 adults with synucleinopathies—diseases like Parkinson's, Lewy body dementia, and multiple system atrophy—to learn how they develop and change over time. Researchers will track symptoms, biological markers, and early signs like dizziness on standing or dream…

This study looks at the challenges faced by people with isolated REM sleep behavior disorder (iRBD) and their caregivers. iRBD causes people to act out their dreams during sleep and is linked to future brain diseases. Researchers will ask 150 patients and their partners about the…