REM SLEEP BEHAVIOR DISORDER

This phase 2 trial is testing whether a 6-month program of online exercise classes, guided meditation, and nutrition guidance can improve thinking, sleep, and brain health in people with Parkinson's disease. Researchers will measure changes in cognition, inflammation, gut bacteri…

This study tests a behavioral (non-drug) treatment to reduce nightmares in adults with REM sleep behavior disorder (RBD). Participants attend 7 video sessions, with a family member joining 2 of them. The goal is to see if the therapy lowers nightmare frequency and severity.

This study is investigating whether people with REM sleep behavior disorder (RBD) have a higher history of concussions or contact sports compared to those without RBD. Researchers will interview 140 participants (70 with RBD and 70 without) about their past head injuries and spor…

This observational study surveys 150 people with isolated REM sleep behavior disorder (iRBD) and their caregivers. iRBD causes people to act out dreams during sleep and is linked to future brain diseases. The study asks about their emotional well-being, access to information, and…

This study follows 640 participants—including people with Parkinsonism, a sleep disorder called REM sleep behavior disorder, and healthy volunteers—for 5 years. Researchers use brain scans, movement tests, blood samples, and voice recordings to track how the disease changes over …

This study looks at immune cells in the gut to understand how they might be involved in brain diseases like multiple sclerosis and Parkinson's. Researchers will collect tissue samples from 100 adults during colonoscopies. The goal is to learn more about the gut's role in these co…

This study aims to create a large national collection of blood and tissue samples from 230 people with Parkinson's disease or a related sleep disorder. Researchers will analyze the complete genetic code of participants and create stem cell lines to study how gene combinations con…

This study looks at how the brain changes over time in people with REM sleep behavior disorder, a condition that often leads to Parkinson's disease or similar disorders. Researchers will use brain scans and thinking tests to track these changes in about 86 adults. The goal is to …

This study follows 800 adults with synucleinopathies—diseases like Parkinson's, Lewy body dementia, and multiple system atrophy—to learn how they develop and change over time. Researchers will track symptoms, biological markers, and early signs like dizziness on standing or dream…