Primary progressive aphasia

This study tests a drug called neflamapimod in 20 people with a language disorder called nonfluent variant primary progressive aphasia (nfvPPA). The goal is to see if the drug is safe and if it can improve language symptoms. Participants will receive either the drug or a placebo …

This study tests whether adding a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) to speech therapy can improve language skills in people with primary progressive aphasia (PPA), a condition that slowly damages language areas of the brain. A…

This study tests whether a gentle, low-level electric current applied to specific brain areas can improve speech and language difficulties in people with primary progressive aphasia (PPA) and progressive apraxia of speech (PAOS). The treatment is called high-definition transcrani…

This study tests two types of speech therapy for people with primary progressive aphasia, a brain disorder that slowly destroys language skills. Sixty participants will work on word retrieval or script practice with a clinician and at home. Researchers will measure changes in com…

This study tests whether combining speech therapy with a gentle brain stimulation technique (tDCS) can help people with primary progressive aphasia (PPA) communicate better. Ten participants will receive treatment at home via video calls. The goal is to see if this approach is fe…

This study tests a speech-language telerehabilitation program for people with primary progressive aphasia (PPA), a dementia that slowly destroys language abilities. The program includes online therapy sessions and care partner training. Researchers will enroll 21 participants to …

This study uses advanced MRI scans and genetic tests to track how neurodegenerative diseases like frontotemporal dementia and ALS spread across the brain's network. Researchers will follow 645 participants, including patients, family members, and healthy controls, for up to 2 yea…

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions over time, using brain scans and genetic tests to see how the diseases progress. T…

This observational study looks at how brain inflammation contributes to frontotemporal lobar degeneration (FTLD), a group of disorders that cause dementia. Researchers will use advanced brain scans, blood tests, and spinal fluid analysis in 110 participants to find biomarkers tha…