Can speech therapy slow language loss in progressive aphasia?
NCT ID NCT04881617
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests two types of speech therapy for people with primary progressive aphasia, a brain disorder that slowly destroys language skills. Sixty participants will work on word retrieval or script practice with a clinician and at home. Researchers will measure changes in communication and use brain scans to see who benefits most.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Lexical Retrieval Training and Video-Implemented Script Training for Aphasia (behavioral therapy)
- What this could lead to
- If it works, this could provide evidence-based speech therapy methods to help people with primary progressive aphasia communicate better for longer.
- What could go wrong
- This is a small, early-stage study with only 60 participants, and the disease is progressive, so any improvements may be temporary or not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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60 people
The number who actually took part.
- Started
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Jul 2017
- Expected to finish
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Dec 2025
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011) * Score of 15 or higher on the Mini-Mental State Examination Exclusion Criteria: * Other neurological or psychiatric diagnosis that may contribute to cognitive-linguistic deficits * Significant, uncorrected visual or hearing impairment that would interfere with participation * Score of less than 15 on the Mini-Mental State Examination * Prominent initial non-speech-language impairment (cognitive, behavioral, motoric)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of California San Francisco
San Francisco, California, 94158, United States
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University of Texas
Austin, Texas, 78712, United States
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Other studies related to the condition(s) this trial covers.
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