Prelingual non-syndromic genetic hearing loss
MONDO:0016297A rare, genetically highly heterogeneous otorhinolaryngologic disease, resulting from inner and/or middle ear or hearing nerve anomalies, typically characterized by bilateral, severe to profound hearing loss (mean sensorineural hearing impairment of 60 dB or more for 500-, 1,000-, and 2,000-Hz frequency tones in the better ear) which occurs before the onset of speech development and is not associated with visible external ear abnormalities or any other medical problems. It is usually nonprogressive and impedes oral language acquisition.
Also known as: prelingual non-syndromic genetic hearing loss, isolated prelingual genetic deafness, prelingual non-syndromic genetic deafness
37 clinical trials for this condition and its sub-types, 5 tagged with Prelingual non-syndromic genetic hearing loss itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Prelingual non-syndromic genetic hearing loss
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New cochlear implant aims to help those with partial hearing hear better
Disease control CompletedThis study tested a new cochlear implant (CI632) in 10 adults who have some low-frequency hearing but poor high-frequency hearing. The goal was to see if the implant improves speech understanding and overall hearing. Participants received the implant and were followed to measure …
Sponsor: Cochlear • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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Could a Child's own cord blood stem cells restore hearing?
Disease control CompletedThis study tests whether infusing a child's own stored umbilical cord blood stem cells is safe for children with acquired sensorineural hearing loss. The trial enrolls children with moderate to profound hearing loss and aims to see if the infusion can improve inner ear function, …
Phase 1 • Sponsor: James Baumgartner, MD • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Could talking it out boost hearing aid success?
Symptom relief CompletedThis trial tests whether communication training helps first-time hearing aid users with mild to moderate hearing loss adapt better. Participants receive training either in a group or one-on-one, and researchers compare their hearing-related quality of life, communication strategi…
Sponsor: University Ghent • Aim: Symptom relief
Last updated Sep 03, 2026 00:00 UTC
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Can a simple supplement quiet tinnitus and save your hearing?
Symptom relief CompletedThis study tested a daily dietary supplement called ACEMg (Soundbites) in 64 adults with hearing loss or tinnitus. Participants took the supplement for 24 weeks and completed hearing tests and symptom surveys at home using a smartphone app. The goal was to see if the supplement c…
Sponsor: Keep Hearing, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Acupuncture meets modern medicine: can a herb injection ease hearing loss and vertigo?
Symptom relief CompletedThis completed study tested whether adding gastrodin acupoint injections to standard care helps people with sudden hearing loss and vertigo. One hundred adults received either standard therapy alone or standard therapy plus injections into specific acupuncture points over four we…
Sponsor: The First Hospital of Hebei Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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Scientists hunt for genes behind hearing loss and dizziness
Knowledge-focused CompletedThis study aims to find the genetic causes of hereditary hearing loss and balance disorders. Researchers will study families with these conditions, collecting medical history, blood or cheek swabs, hearing and balance tests, and sometimes scans. The goal is to identify genes and …
Sponsor: National Institute on Deafness and Other Communication Disorders (NIDCD) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Scientists hunt for genes behind inner ear malformation
Knowledge-focused CompletedThis study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…
Sponsor: National Institute on Deafness and Other Communication Disorders (NIDCD) • Aim: Knowledge-focused
Last updated Aug 06, 2026 00:00 UTC
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Electrical fingerprints may reveal hidden scarring in cochlear implant patients
Knowledge-focused CompletedThis study investigates whether a quick, painless electrical measurement called transimpedance matrix (TIM) can detect scar tissue (fibrosis) that sometimes forms inside the cochlea after cochlear implant surgery. Researchers will compare TIM results with CT scans in 180 adults w…
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jul 11, 2026 00:00 UTC
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Simple signs and amplifiers may cut hospital delirium
Knowledge-focused CompletedThis study looked at whether hearing and vision loss are linked to delirium (sudden confusion) in older hospital patients. Over 1,500 participants answered screening questions and had their hearing and vision tested. In a smaller trial, researchers tested if posting communication…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Inner ear secrets: study aims to predict who will hear better with hearing aids
Knowledge-focused CompletedThis completed study enrolled 186 people with mild to moderate hearing loss to understand how damage to inner ear sensory cells and auditory neurons affects speech understanding, especially in noisy environments. Participants were fitted with hearing aids and tested on speech rec…
Sponsor: Steward St. Elizabeth's Medical Center of Boston, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Scientists hunt for gene behind severe childhood deafness
Knowledge-focused CompletedThis completed study looked at 150 children with severe to profound hearing loss to find how many have a specific genetic form called DFNB9. Researchers collected medical and genetic data from routine care. The goal was to better understand this condition and pave the way for fut…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Study tracks how cochlear implants affect Kids' brain and speech over 3 years
Knowledge-focused CompletedThis study followed 50 children who received cochlear implants, measuring their brain's electrical responses to sounds and comparing them with speech and language test results over three years. The goal was to see if certain brain wave patterns could predict how well a child deve…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:59 UTC