Precancerous condition

This study tests if injecting the cancer drug nivolumab directly into high-risk precancerous mouth lesions can stop them from turning into cancer. About 45 adults with these lesions will receive either the drug or a placebo injection. The goal is to see if the treatment is safe a…

This study tests whether a procedure called endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) can safely treat pancreatic lesions. The approach uses a special endoscope to deliver heat energy directly to the lesion. Researchers will enroll 60 people with pre-malignan…

This phase 2 trial is testing a new treatment called Orca-T for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Orca-T is a personalized cell therapy made from a donor's blood that includes stem cells and immune cells. The goal is to see if it can impr…

This study tests a reformulated gel (Levulan Kerastick) combined with blue light therapy to treat actinic keratosis, a common precancerous skin condition. About 160 adults with 4 to 8 mild-to-moderate spots on the face or bald scalp will receive either the active gel or a placebo…

This study tests a reformulated cream (Levulan Kerastick) plus blue light therapy for actinic keratosis, a common precancerous skin condition. About 260 adults with 4-8 spots on one arm will receive either the active treatment or a placebo cream, followed by light exposure. The m…

This study compares two endoscopic procedures—argon plasma coagulation (APC) and endoscopic mucosal resection (EMR)—for treating small (1 cm or smaller) precancerous growths in the stomach called gastric adenomas with low-grade dysplasia. About 160 adults will be randomly assigne…

This phase II trial tests whether artesunate, a drug originally used for malaria, can reverse cervical pre-cancer (CIN2/3) when given as a vaginal insert. About 78 women with high-grade cervical lesions will receive either artesunate or a placebo for three 5-day cycles. The main …

This study is collecting vaginal fluid samples from 4,200 people to develop a new test for endometrial cancer. Participants include those with abnormal uterine bleeding or a recent endometrial cancer diagnosis. The goal is to find biomarkers that could lead to a simple, non-invas…

This study is testing a new urine test that aims to detect colorectal cancer and precancerous polyps early. Researchers will enroll 210 people in Ghana, Tanzania, and South Africa who have symptoms like rectal bleeding or are getting a colonoscopy. The test uses a biosensor to fi…

This study compares two non-invasive techniques—a cell-collection brush test and a special microscope—to see if they can accurately detect precancerous and early cancerous spots in the mouth. Researchers will enroll 400 adults with visible mouth lesions. If successful, these meth…

This study is testing a new, low-cost screening tool for cervical cancer that uses artificial intelligence to analyze digital images of the cervix. It does not require a lab and can be used at the point of care. The goal is to see if this AI tool can accurately detect precancerou…

This study is testing a new blood test called PanTum Detect to see how well it can find early signs of cancer or pre-cancer. The test looks for certain markers in immune cells. Researchers will compare the blood test results with standard PET/CT scans in 134 adults—half with susp…

This study is testing a new immune therapy called RP2, made from a modified herpes virus, to treat high-risk oral precancerous conditions and prevent them from turning into oral cancer. The therapy is injected directly into the lesion. The trial will enroll 25 people and look at …

This study tests a mobile app that gives personalized instructions for colonoscopy preparation, including diet and laxative timing. About 470 people aged 50-69 in a colorectal cancer screening program will use the app or standard instructions. The goal is to see if the app helps …

This study follows 135 women who have had breast reconstruction after mastectomy using a special dissolvable mesh called TIGR® Matrix. The goal is to see how the mesh affects their quality of life over three years. Participants will fill out a questionnaire about their symptoms a…

This study collects extra blood, urine, and tumor samples from children and adults with certain cancers to build a large tissue repository. Researchers will analyze these samples to learn more about the genetic and molecular makeup of these tumors. The goal is to support future s…

This study collects blood, bone marrow, and tumor samples from 500 adults with cancer or pre-cancerous conditions. Researchers will use these samples to learn more about how cancers behave and why some respond differently to treatments. Participants provide samples over time and …

This study is a registry that will follow 50 adults who are already scheduled to receive EUS-guided radiofrequency or microwave ablation for pancreatic or other gastrointestinal lesions as part of their routine care. Researchers will collect data from medical records to see how t…

This study is investigating whether exposure to microplastics is linked to the development of stomach cancer and its early stages. Researchers will ask 450 people with different stomach conditions to fill out a detailed questionnaire about their possible exposure to microplastics…

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study is gathering images from special cameras and CT scans, along with lab results, to create a database for early upper gastrointestinal cancers and precancerous conditions. About 500 adults who need certain procedures will take part. The goal is to help doctors better rec…

This study collects tissue, blood, urine, and stool samples from 5000 people undergoing colonoscopy or endoscopy, including those with cancer, polyps, or inflammatory bowel disease, as well as healthy volunteers. The goal is to find new biomarkers that could improve early detecti…

This research study collects sputum and tissue samples from 700 people with precancerous changes or certain cancers (lung, head and neck, esophageal). The goal is to find biomarkers—biological signs—that could help understand or detect these cancers earlier. Participants include …

This study compares two minimally invasive surgical techniques—laparoscopic and robot-assisted—for removing the left side of the pancreas in people with benign or pre-cancerous growths. About 256 participants will be randomly assigned to one of the two procedures. The goal is to …