Pleural tuberculosis

Researchers at a Malaysian hospital reviewed ten years of records for 160 adults who received intrapleural fibrinolytic therapy, a mix of alteplase and DNase delivered through a chest tube, for complicated pleural infection. The study compares how well the treatment cleared fluid…

This study looks at whether two simple calculations, called Cancer Ratio and Cancer Ratio Plus, can help doctors tell the difference between fluid around the lungs caused by cancer and fluid caused by tuberculosis. These calculations use results from routine blood and fluid tests…

This study tests a community-based screening strategy for tuberculosis (TB) in migrant communities in New York City. A mobile van offers digital chest X-rays with AI interpretation, along with TB symptom checks, blood tests for latent TB, and HIV testing. The goal is to see wheth…

This large study in five countries will test new, portable diagnostic tools for tuberculosis (TB) that use tongue swabs and AI-assisted chest X-rays. The goal is to see if these faster, easier tests can find more TB cases, especially in people who have no symptoms or can't produc…

This study tests whether analyzing chemicals in a person's breath can quickly identify serious respiratory infections like COVID-19, flu, and Legionella in hospitalized patients. Researchers will collect breath samples from 777 adults using a simple bag, then analyze them in a la…

This study aims to see if analyzing chemicals in a person's breath can rapidly detect respiratory infections like COVID-19 or the flu. Researchers will collect breath samples from 1,665 adults with symptoms and healthy volunteers. If successful, this non-invasive test could offer…

This study tests whether a rapid PCR test done right in the clinic can help doctors diagnose and treat acute respiratory infections faster. Over 16,000 adults at risk of severe illness will take part. The goal is to see if this approach lowers rates of respiratory failure and hos…

This trial tests whether giving children a probiotic called Saccharomyces boulardii alongside a common antibiotic can prevent diarrhea, a frequent side effect. Children aged 6 months to 5 years with upper respiratory infections will receive either the antibiotic alone or the anti…

This study looks at how well and how safely SIROPSEDAL syrup works for acute cough caused by colds or upper respiratory infections. About 124 children and adults will take the syrup as prescribed by their doctor and report their cough severity over one week. The main goal is to s…

This study tests whether an ultrasound-guided nerve block (erector spinae plane block) provides better pain relief than standard local anesthesia during a lung procedure called medical thoracoscopy. One hundred adults scheduled for this procedure will be randomly assigned to rece…

This study looks at whether a fast, bedside test (SPOTFIRE) can help doctors better treat children with respiratory infections in the emergency department. About 720 children aged 2 months to 18 years will be randomly assigned to either get the rapid test or standard care. The go…

Researchers are following about 1,200 children in Zhejiang Province, China, from birth through age 7 to understand how the immune system develops and why some children get more respiratory infections or asthma. The study includes healthy children, children with a history of serio…

This study aims to better understand tuberculosis (TB) across its entire spectrum—from early, symptom-free infection to active disease and after treatment. Researchers will recruit TB patients and their close contacts to analyze immune responses and identify biomarkers that could…

This study examines data from up to 70,000 patients hospitalized with respiratory tract infections in Dutch hospitals between 2018 and 2026. Researchers will analyze how long patients stay, how many need intensive care, and the overall costs. The goal is to help improve hospital …

This study looks at vitamin D levels in 63 critically ill children (ages 1 month to 12 years) admitted to the ICU with severe breathing infections. Researchers will measure vitamin D in the first 24 hours and compare it to how severe the infection is and the risk of death. The go…

This study looks at how different features of an AI system affect the way primary care doctors diagnose and treat respiratory infections. About 3,000 doctors in China will use a web-based tool with various AI features, such as automated data entry or stepwise medication suggestio…

This study will examine gut bacteria, immune markers, and nutrient levels in 120 children with different respiratory health conditions, including pneumonia and recurrent infections, compared to healthy kids. By analyzing stool samples and health data, researchers hope to understa…

This study will observe 300 children and young adults (ages 0-20) with respiratory tract infections to see if chest ultrasound can predict their outcomes, such as need for hospitalization or ICU care. Researchers will use an ultrasound score and combine it with clinical data to s…