Paroxysmal atrial fibrillation

This study tests a new device called the VariPulse catheter, which uses short electrical pulses to treat atrial fibrillation (AF), a common heart rhythm problem. Twenty adults with AF will get this treatment, and after 2-3 months, doctors will check if the treated veins are still…

This study tests a new device that uses heat to destroy tiny areas in the heart causing short bursts of irregular heartbeat (paroxysmal atrial fibrillation). About 300 adults with this condition will receive the procedure and be monitored for a year. The goal is to see if the tre…

This study is testing a new device that uses pulsed electric fields to treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. The procedure aims to isolate the pulmonary veins to restore normal rhythm. Researchers will enroll 440 people who have not …

This study looks at how safe and effective a new treatment called FARAPULSE pulsed field ablation is for people with a type of irregular heartbeat called paroxysmal atrial fibrillation. About 228 participants will be followed for up to 12 months to see if the procedure stops the …

This study looks at how well a special catheter (THERMOCOOL SMARTTOUCH SF) and software (Ablation Index) work to treat paroxysmal atrial fibrillation, a type of irregular heartbeat. Researchers will track 150 adults who get this procedure to see if they stay free of heart rhythm …

This study compares two ways of doing a heart procedure called catheter ablation for people with atrial fibrillation (an irregular heartbeat). One method uses X-rays to guide the doctor, and the other does not. The goal is to see if the no-X-ray method works just as well and is a…

This study tests whether giving extra fluids (saline) through an IV during and after a heart procedure called pulsed field ablation can prevent acute kidney injury. The procedure is used to treat atrial fibrillation, a common heart rhythm problem, but can sometimes harm the kidne…

This study tests a new approach called 'pill-in-pocket' anticoagulation for people with atrial fibrillation (AF), a heart rhythm condition that raises stroke risk. Instead of taking blood thinners every day, participants would stop them after a 30-day AF-free period and only rest…

This trial compares standard versus extra pulsed field ablation applications during pulmonary vein isolation in people with atrial fibrillation. The goal is to see if more targeted ablations improve freedom from irregular heart rhythms for up to 18 months. Participants are adults…

This trial tests whether using a larger, expandable balloon during cryoablation for paroxysmal atrial fibrillation better affects the heart's autonomic (automatic) control compared to a standard-size balloon. About 40% of patients show signs of beneficial parasympathetic denervat…

This study tests a new device that uses pulsed electric fields to treat persistent atrial fibrillation, a type of irregular heartbeat. Researchers will enroll 200 people to see if the procedure is safe and can restore normal heart rhythm. The goal is to offer a more precise and l…

This study tests whether adding a kidney nerve treatment (renal denervation) to a repeat catheter ablation for atrial fibrillation (AFib) can lower the chance of AFib coming back. About 250 people with high blood pressure and AFib who need a second ablation will be randomly assig…

This study tests a new device that uses special electrical pulses to treat paroxysmal atrial fibrillation, a condition where the heart beats irregularly. About 150 adults aged 18-75 who have not responded well to medication will receive the treatment. The goal is to see if the de…

This study tests a new device system that uses pulsed electric fields to treat atrial fibrillation, a common heart rhythm problem. About 300 people with symptomatic, recurrent atrial fibrillation will receive the procedure. The goal is to see if it safely and effectively restores…

This study compares two catheter ablation techniques for atrial fibrillation (AF), a condition where the heart beats irregularly. One method uses a standard approach with a drug called adenosine to find missed spots, while the other adds an extra ring of ablation without the drug…

This study looks at two ways to treat a type of irregular heartbeat called non-paroxysmal atrial fibrillation (AFib) that doesn't go away on its own. Both methods use a new technique called pulsed-field ablation to destroy tiny areas of heart tissue causing the problem. One group…

This study tests a device called the Farapulse system, which uses electrical pulses to treat atrial fibrillation (AFib), a common heart rhythm problem. Researchers will enroll 275 adults with AFib who are already scheduled for a catheter ablation procedure. The goal is to see if …

This study compares two ways to treat a heart condition called atrial fibrillation (AFib) that causes an irregular heartbeat. The standard method uses freezing (cryoballoon), while the newer method uses electrical pulses (pulsed field ablation). The goal is to see if the new meth…

This study tests whether measuring amiodarone levels in the blood helps doctors choose the right dose for people with paroxysmal atrial fibrillation (a type of irregular heartbeat). About 80 adults will receive different daily doses (100, 200, or 400 mg) and be monitored for thre…

This study tests a new device called the Globe Pulsed Field System to treat people with atrial fibrillation (AF), a common heart rhythm problem. The device uses electrical pulses to destroy small areas of heart tissue causing the irregular rhythm. About 549 participants will be f…

This pilot study was designed to test a new, more targeted way to perform ablation for atrial fibrillation (AFib). Instead of burning a wide area around the pulmonary veins, doctors would use special mapping technology to precisely target the heart muscle sleeves causing the abno…

This study looks at whether using a CPAP machine at night can reduce the chance of atrial fibrillation (an irregular heartbeat) returning in people who have both sleep apnea and a history of AF. Researchers will follow 91 adults for 12 months, tracking how often they use CPAP and…

This study tests a new balloon catheter that uses pulsed electric fields instead of heat to treat atrial fibrillation (AFib), a common heart rhythm problem. About 35 adults with short-lasting AFib will receive the procedure. The goal is to see if the balloon safely and effectivel…

This study tracks 344 adults with paroxysmal atrial fibrillation (a type of irregular heartbeat) who are having their first catheter ablation procedure using a specific device. The goal is to see how well the procedure works and how safe it is in everyday medical practice. Resear…

This study tests whether using an implantable heart monitor (or a wearable patch) to detect atrial fibrillation early after catheter ablation can reduce the total time spent in AF. About 120 people with paroxysmal or persistent AF will be monitored for 15 months. The goal is to s…

This trial tests a new device called the Synaptic Cryoablation System, which uses a balloon to freeze small areas of the heart and correct irregular heartbeats in people with paroxysmal atrial fibrillation. 128 participants will receive the treatment and be followed for 12 months…

This study will test whether an artificial intelligence (AI) program can accurately detect atrial fibrillation (AF) using data from consumer smartwatches. Researchers will enroll 40 adults with AF who will wear a smartwatch while their heart rhythm is also monitored with standard…

This study looks at whether a new computer algorithm can predict if atrial fibrillation (an irregular heartbeat) will come back after a common treatment called pulmonary vein isolation. Researchers will review medical records from 300 patients who had this procedure. The goal is …

This study looks at two methods for treating atrial fibrillation (an irregular heartbeat) using a special balloon catheter. The goal is to see if using a 3D mapping system (CARTO) makes the procedure faster and safer than using X-ray guidance alone. About 60 adults with paroxysma…

This study looks at whether actively cooling the esophagus during a common heart procedure (ablation for atrial fibrillation) helps improve outcomes and reduce side effects. Researchers will follow 312 adults with symptomatic atrial fibrillation who are already scheduled for abla…

This study was designed to see if a new, ultra-sensitive mapping technique could better confirm that cryoballoon ablation successfully isolated the pulmonary veins in patients with paroxysmal atrial fibrillation. The trial was withdrawn before enrolling any participants, so no re…