Pancreatitis

Severe acute pancreatitis causes the pancreas to swell dangerously, and pressure building inside the abdomen can lead to organ failure. Researchers at a Shanghai hospital are testing whether adding Da-Cheng-Qi Decoction, a classic Chinese herbal formula, to standard Western treat…

Researchers test a blood purification device called Efferon CT combined with high-volume hemofiltration in adults with acute pancreatitis. The goal is to see if removing inflammatory molecules from the blood reduces organ dysfunction and improves recovery. The trial enrolls 28 pa…

This study tested a drug called Auxora in 216 people hospitalized with acute pancreatitis and systemic inflammatory response syndrome (SIRS), a serious body-wide inflammation. Participants received either Auxora or a placebo daily for three days. The main goal was to see if Auxor…

This trial tests whether the type of IV fluid given to people with acute pancreatitis affects how severe the disease becomes. About 800 adults with acute pancreatitis will be randomly assigned to receive either lactated Ringer's solution or normal saline for at least 48 hours. Th…

This trial tests whether epidural analgesia—pain medicine delivered near the spinal cord—can help people with severe acute pancreatitis breathe better and avoid needing a breathing machine. About 148 ICU patients with severe pancreatitis will be randomly assigned to receive eithe…

This study tests whether adding a traditional Chinese herbal enema (Tongfu Qinghua Decoction) and an external herbal powder (Ruyi Jinhuang Powder) to standard medical care can help adults with acute pancreatitis recover faster. The trial enrolled 100 people aged 18 to 75 with the…

This study tested two anti-inflammatory drugs (etanercept and alpha-1 antitrypsin) in 43 adults with severe chronic pancreatitis who had their pancreas removed and their insulin-making cells (islets) transplanted into the liver. The goal was to see if these drugs could protect th…

This study tested an experimental drug called CM4620-IE in 21 people with severe pancreatitis that caused body-wide inflammation (SIRS). The goal was to see if the drug is safe and to find the best dose for future studies. Participants received the drug plus standard care or stan…

This study looks at whether a urine test can quickly detect pancreatitis after pancreas removal surgery. About 50 adults having elective pancreatectomy will provide urine samples before, during, and after surgery. The results will be compared with standard blood tests to see if t…

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study looked at new markers in blood and urine to detect and predict the severity of drug-associated acute pancreatitis in adults. Researchers compared these markers in 175 patients with drug-induced pancreatitis, other pancreatic diseases, and healthy volunteers. The goal i…

This study tested whether giving rectal indomethacin (an anti-inflammatory drug) along with extra fluids before an ERCP procedure could prevent pancreatitis, a painful complication. The trial included 60 patients who needed ERCP. The goal was to see if this simple, low-cost appro…

This study looked at whether giving more IV fluids (aggressive hydration) during an ERCP procedure can prevent pancreatitis, a common complication. 126 adults having their first ERCP were randomly assigned to receive either standard or extra fluids. The goal was to see if extra f…

This study tested whether rinsing the duodenal papilla with cold (3°C) sterile saline right after an ERCP procedure can lower the risk of post-ERCP pancreatitis. 900 adults in Colombia were randomly assigned to receive the cold saline rinse or standard care. The main goal was to …

This study tested whether a procedure called ERCP with sphincterotomy can lower the risk of repeat pancreatitis attacks in people with pancreas divisum, a condition where the pancreas ducts don't join normally. 181 adults who had at least two pancreatitis episodes were randomly a…

This study tested a web-based program to help children aged 10-19 with chronic or recurring pancreatitis manage their abdominal pain. The program teaches cognitive behavioral skills to reduce pain and improve quality of life. 90 participants were enrolled, and the study measured …

This study tested a non-invasive device that stimulates a nerve in the ear (taVNS) to see if it can calm inflammation and improve gut function in people with acute pancreatitis. Sixty adults with early-stage pancreatitis received either the real stimulation or a sham device. The …

This study tested a small, needle-free device that sends mild electrical pulses to specific points on the skin to relieve abdominal pain in people with chronic pancreatitis. 42 adults with long-term pancreas pain used the device at home for several weeks. The goal was to see if t…

This study tested a mobile app that gives personalized encouragement and health insights based on blood sugar, exercise, mood, and sleep patterns. The goal was to help 24 middle-aged adults with type 1 diabetes or similar conditions exercise more often and confidently. The app ai…

This observational study will monitor 1,000 patients in Slovakia and Czechia who undergo ERCP, a procedure to treat bile duct problems. The main goal is to track how often pancreatitis occurs after the procedure and whether hospitals are following recommended prevention steps. Th…

This study reviewed medical records of 148 adults admitted to the ICU with severe acute pancreatitis. The goal was to find risk factors for infected pancreatic necrosis, a serious complication that raises the risk of death. By identifying these factors, doctors hope to diagnose a…

This completed study looked at 141 people with acute pancreatitis to understand how blood clotting changes during the illness. Researchers took blood samples over several days and will analyze them for markers that might predict whether the disease becomes mild, moderate, or seve…

This study looked at whether enzyme therapy helps people with chronic pancreatitis absorb protein better. Eleven participants took part to measure how their bodies used dietary nitrogen. The goal was to understand if current enzyme treatments are effective for protein digestion.

This completed study looked at data from over 723,000 older adults (70+) worldwide to understand how common pancreatic cancer and pancreatitis are, and how deadly they are. Researchers analyzed trends from 1990 to 2021 and made projections to 2040. The goal was to see how these d…