Orthocoronavirinae infectious disease

This study tested an experimental vaccine called VBI-2901a in 103 healthy adults aged 18-64 who had already received at least two doses of a licensed COVID-19 vaccine. The vaccine is designed to protect against three coronaviruses: SARS-CoV-2 (which causes COVID-19), SARS-CoV-1, …

This study tested the CoviVac COVID-19 vaccine in 200 healthy adults aged 60 and older. Researchers checked how safe the vaccine was and how well it boosted the immune system. The goal was to see if the vaccine could help prevent COVID-19 in this age group.

This study tested three new self-amplifying RNA vaccines against COVID-19 in 72 healthy adults, some already vaccinated and some not. The goal was to check safety and how well the vaccines boost the immune system. Results help decide which vaccine candidates to study further.

This study tested a new COVID-19 vaccine called ChAdOx1 nCoV-19 in over 1,000 healthy adults aged 18-55 in the UK. The goal was to see if the vaccine is safe, triggers an immune response, and can prevent COVID-19. Participants received either the vaccine or a comparison shot, and…

This large, completed trial tested several potential COVID-19 treatments in over 1,500 hospitalized adults across Europe. Earlier drugs like remdesivir and hydroxychloroquine were dropped after showing no benefit. The current phase is testing a new antibody combination called AZD…

This study tests an experimental drug called SPI-1005 (ebselen) in adults hospitalized with severe COVID-19. Participants receive either the drug or a placebo to see if the drug is safe and helps improve recovery. The trial is randomized and double-blind, meaning neither patients…

This study tested whether giving early treatment to adults with COVID-19 who have risk factors (like age over 60 or high blood pressure) could prevent them from needing oxygen, hospitalization, or dying. About 412 people took part. The goal was to see if these treatments are safe…

This study tested whether breathing in nitric oxide gas can improve oxygen levels in severely ill COVID-19 patients who are on ventilators. Researchers enrolled 200 adults in the ICU with confirmed COVID-19 and severe breathing problems. Patients received either standard care plu…

This phase 3 study tested the drug sarilumab (Kevzara®) in 420 adults hospitalized with severe or critical COVID-19. Participants received either sarilumab or a placebo by IV. The main goal was to see if sarilumab speeds up clinical improvement. The trial also tracked survival, n…

This study tests two new devices (imPulse Una and TOR) that use sound waves to detect COVID-19, flu, and RSV without needles or swabs. About 300 adults with or without symptoms will have a quick, painless scan. The goal is to see if these e-stethoscopes can accurately identify th…

This study tested a 30-week walking program for cancer survivors who had been hospitalized with COVID-19. The goal was to see if the exercise was safe and caused few side effects. Only 3 people took part, so the results are very early and not conclusive.

This study looked at children and young adults under 24 who had COVID-19, including those with cancer. Researchers collected samples and medical information to learn about symptoms, risk factors, and how the virus spreads. The goal was to better understand the disease in younger …

This study looked at nearly 2,000 adults with lung cancer who caught COVID-19. Researchers tracked their health and checked for antibodies (immune system markers) right after infection and again 6 months after vaccination. The goal was to understand how lung cancer affects the bo…

This study looked at how T-cells, a key part of the immune system, respond to the COVID-19 virus in 51 people—hospitalized patients and healthy hospital staff. Researchers measured T-cell activity at several time points using a blood test called ELISPOT. The goal was to better un…

This completed registry study collected data from 500 COVID-19 patients to learn how the virus affects kidney function. Researchers aimed to identify risk factors and track outcomes. The findings may help guide future treatment and care for kidney complications in COVID-19.

This study looked back at how French hospitals created more intensive care unit (ICU) beds and found extra healthcare workers during the COVID-19 pandemic. Researchers gathered information from nearly 10,000 hospitals across France. The goal was to understand where the new beds c…

This study followed over 1,000 adults with confirmed or suspected COVID-19 who were admitted to intensive care units (ICUs) across France. Researchers tracked their treatments, complications, and survival at 28 days. The goal was to learn how these patients are managed and what f…

This study followed 211 older adults who were hospitalized with COVID-19 to see how their mobility and daily function changed over time. Researchers measured physical abilities like walking, balance, and thinking skills. The goal is to understand recovery patterns so doctors can …