Neuroma

This study tests a small absorbable cap placed over cut nerve endings during finger amputation surgery. The goal is to prevent painful neuromas (nerve balling) that often cause chronic pain. Twenty adults who have had a traumatic finger amputation will be followed for up to a yea…

This study is testing special screws that dissolve over time, used in foot and ankle surgeries for fractures, realignments, or joint fusions. The screws are meant to hold bones together while they heal, then safely absorb into the body. Researchers will follow 125 adults for 4 ye…

This study explores whether a 7 Tesla MRI scanner can produce clearer images of the foot and ankle than standard MRI. Researchers will scan people with known foot problems—like plantar plate tears or Morton neuroma—and healthy volunteers to see if the higher-powered machine detec…

This trial tests whether short-term implanted electrodes can improve the signals used to control advanced prosthetic arms and hands in people who have had an upper-limb amputation. Participants will have electrodes placed after a regenerative peripheral nerve interface (RPNI) sur…

This study looks at two types of nerve surgery to treat stubborn pain after amputation (phantom limb pain and stump pain). About 98 adults who have had pain for at least 6 months and haven't had prior pain surgery will be followed for 2 years. The goal is to see if either surgery…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study looks at whether a surgery called RPNI can reduce nerve pain in people who have had a leg amputated. The surgery takes the cut nerve end and wraps it in a small piece of the patient's own muscle to help it heal. Researchers will follow 20 adults for 24 months to see if…

Morton's neuroma causes burning or shooting pain in the ball of the foot, often in middle-aged women. This study compares freezing the nerve (cryoablation) plus a steroid/lidocaine injection against the injection alone. 32 adults who haven't improved with orthotics or pads will b…

This study tests a surgical technique called targeted muscle reinnervation (TMR) to prevent phantom limb pain and stump pain after a leg amputation. About 200 adults having a leg amputation due to blood vessel disease will be randomly assigned to receive either TMR or standard ne…