Please sign in to follow a disease.
Movement disorder
MONDO:0005395Neurological conditions resulting in abnormal voluntary or involuntary movement, which may impact the speed, fluency, quality and ease of movement.
Also known as: movement disease, movement disorder, movement disorders
805 clinical trials for this condition and its sub-types, 108 tagged with Movement disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Movement disorder
-
Extrapyramidal and movement disease 0 trials · 149 incl. sub-types
1 sub-type
- Dystonic disorder 65 trials · 149 incl. sub-types Sub-types →
-
Cerebellar ataxia 40 trials · 144 incl. sub-types
1 sub-type
- Hereditary cerebellar ataxia 0 trials · 116 incl. sub-types Sub-types →
-
Multiple system atrophy 110 trials · 119 incl. sub-types
4 sub-types
- Pure autonomic failure 18 trials
- Multiple system atrophy, parkinsonian type 12 trials
- Multiple system atrophy, cerebellar type 3 trials
- Striatonigral degeneration 0 trials Sub-types →
-
Essential tremor 102 trials · 104 incl. sub-types
6 sub-types
- Tremor, hereditary essential, 1 2 trials
- Tremor, hereditary essential, 2 0 trials
- Tremor, hereditary essential, 3 0 trials
- Tremor, hereditary essential, 4 0 trials
- Tremor, hereditary essential, 5 0 trials
- Tremor, hereditary essential, 6 0 trials
-
Progressive supranuclear palsy 74 trials · 78 incl. sub-types
4 sub-types
- Supranuclear palsy, progressive, 1 5 trials
- Atypical progressive supranuclear palsy syndrome 1 trial · 4 incl. sub-types Sub-types →
- Supranuclear palsy, progressive, 2 0 trials
- Supranuclear palsy, progressive, 3 0 trials
-
Huntington disease 76 trials
2 sub-types
- Juvenile Huntington disease 1 trial
- Westphal disease 0 trials
-
Progressive non-fluent aphasia 24 trials · 44 incl. sub-types
1 sub-type
- Semantic dementia 32 trials Sub-types →
-
Behavioral variant of frontotemporal dementia 22 trials · 42 incl. sub-types
3 sub-types
-
Tourette syndrome 41 trials
-
Corticobasal syndrome 20 trials
-
Frontotemporal dementia with motor neuron disease 14 trials · 19 incl. sub-types
7 sub-types
- Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 5 trials
- Amyotrophic lateral sclerosis type 10 3 trials
- Amyotrophic lateral sclerosis type 6 1 trial
- Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 0 trials
- Frontotemporal dementia and/or amyotrophic lateral sclerosis 3 0 trials
- Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 0 trials
- Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 0 trials
-
Chronic tic disorder 15 trials
-
Choreatic disease 11 trials
5 sub-types
- Chorea gravidarum 0 trials
- Chorea, benign familial 0 trials
- Chorea, remitting, with nystagmus and cataract 0 trials
- Choreoathetosis, familial inverted 0 trials
- Hereditary progressive chorea without dementia 0 trials
-
Neurodegeneration with brain iron accumulation 1 trial · 8 incl. sub-types
14 sub-types
- Neurodegeneration with brain iron accumulation 5 4 trials
- Pantothenate kinase-associated neurodegeneration 4 trials Sub-types →
- PLA2G6-associated neurodegeneration 1 trial Sub-types →
- Kufor-Rakeb syndrome 0 trials Sub-types →
- Woodhouse-Sakati syndrome 0 trials
- Aceruloplasminemia 0 trials
- Early-onset progressive encephalopathy-spastic ataxia-distal spinal muscular atrophy syndrome 0 trials
- Fatty acid hydroxylase-associated neurodegeneration 0 trials
- Neurodegeneration with brain iron accumulation 4 0 trials
- Neurodegeneration with brain iron accumulation 6 0 trials
- Neurodegeneration with brain iron accumulation 7 0 trials
- Neurodegeneration with brain iron accumulation 8 0 trials
- Neurodegeneration with brain iron accumulation 9 0 trials
- Neuroferritinopathy 0 trials
-
Arthrogryposis 4 trials · 6 incl. sub-types
5 sub-types
- Freeman-Sheldon syndrome 1 trial Sub-types →
- Congenital contractural arachnodactyly 1 trial
- Boylan dew greco syndrome 0 trials
- Distal arthrogryposis Moore weaver type 0 trials
- Massa casaer ceulemans syndrome 0 trials
-
Inherited Creutzfeldt-Jakob disease 5 trials
-
Primary orthostatic tremor 5 trials
-
Clonic hemifacial spasm 4 trials
-
Familial congenital mirror movements 3 trials
4 sub-types
- Mirror movements 1 and/or agenesis of the corpus callosum 0 trials Sub-types →
- Mirror movements 2 0 trials
- Mirror movements 3 0 trials
- Mirror movements 4 0 trials
-
Transient tic disorder 3 trials
-
Opsoclonus-myoclonus syndrome 2 trials
-
Lafora disease 1 trial
2 sub-types
- Myoclonic epilepsy of Lafora 1 0 trials
- Myoclonic epilepsy of Lafora 2 0 trials
-
Unverricht-Lundborg syndrome 1 trial
-
Benign shuddering attacks 1 trial
-
Myoclonus, familial 1 trial
2 sub-types
- Myoclonus, familial, 1 0 trials
- Myoclonus, familial, 2 0 trials
-
Psychogenic movement disorders 1 trial
-
PRRT2-associated paroxysmal movement disorder 0 trials · 1 incl. sub-types
3 sub-types
- Episodic kinesigenic dyskinesia 1 1 trial
- Infantile convulsions and choreoathetosis 0 trials
- Seizures, benign familial infantile, 2 0 trials
-
Intellectual disability-hyperkinetic movement-truncal ataxia syndrome 0 trials · 1 incl. sub-types
1 sub-type
-
Huntington disease-like 3 0 trials
-
2 sub-types
-
Sandifer syndrome 0 trials
-
Brain-lung-thyroid syndrome 0 trials
-
1 sub-type
- Torsion dystonia 2 0 trials
-
Epilepsy with myoclonic absences 0 trials
-
Hereditary geniospasm 0 trials
-
Hyperekplexia 0 trials
2 sub-types
- Hereditary hyperekplexia 0 trials Sub-types →
- Sporadic hyperekplexia 0 trials
-
Isolated facial myokymia 0 trials
-
Kuru 0 trials
-
Lingual-facial-buccal dyskinesia 0 trials
-
Neuroacanthocytosis 0 trials
2 sub-types
- VPS13A-related neurodegenerative disease 0 trials
- XK-related neurodegenerative disease 0 trials
Most studied deeper sub-types
-
Spinal injection drug targets genetic cause of ALS and dementia
Disease control Stopped earlyResearchers are testing repeated doses of an experimental drug called WVE-004 in adults who have ALS, frontotemporal dementia, or both, linked to a mutation in the C9orf72 gene. Participants receive the drug by spinal injection every 12 weeks for up to 96 weeks. The study tracks …
Phase 1/2 • Sponsor: Wave Life Sciences USA, Inc. • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
-
Experimental Friedreich's ataxia drug tested in kids – but trial halted early
Disease control Stopped earlyThis early-stage trial tested a drug called nomlabofusp (CTI-1601) in 18 adolescents and children with Friedreich's ataxia, a rare genetic disease that affects movement and coordination. The goal was to check safety and how the body processes the drug. However, the study was term…
Phase 1 • Sponsor: Larimar Therapeutics, Inc. • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
-
Continued EryDex treatment studied in rare neurological disorder
Disease control Stopped earlyThis study offered continued treatment with EryDex to 101 people with ataxia telangiectasia (A-T) who had finished a previous trial. The main goal was to monitor safety, including side effects and serious events. The study was terminated early, and it did not aim to cure the dise…
Phase 3 • Sponsor: Quince Therapeutics S.p.A. • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
-
Experimental drug shows promise for rare genetic disorder
Disease control Stopped earlyThis Phase II trial tested a drug called N-Acetyl-L-Leucine (IB1001) in 17 people with Ataxia-Telangiectasia, a rare genetic disease that affects movement and immunity. The study aimed to see if the drug could improve symptoms and slow the disease over time. The trial was termina…
Phase 2 • Sponsor: IntraBio Inc • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
-
Virus therapy fails to advance in colorectal cancer trial
Disease control Stopped earlyThis study tested a new approach using a virus that attacks cancer cells (oncolytic immunotherapy) along with two standard drugs (atezolizumab and bevacizumab) in people with advanced colorectal cancer that had stopped responding to other treatments. The trial was stopped early a…
Phase 2 • Sponsor: Replimune, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
-
Huntington's drug safety study halted early
Disease control Stopped earlyThis study aimed to see if the drug SAGE-718 is safe for people with Huntington's disease when taken over a long period. It was an open-label study, meaning everyone knew they were getting the drug. The study was terminated early, so results are limited.
Phase 3 • Sponsor: Supernus Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
-
Experimental cell therapy targets deadly childhood brain cancer
Disease control Stopped earlyThis early-phase trial tested a new immunotherapy approach for children with DIPG, a rare and aggressive brain stem tumor. After standard radiation and chemotherapy, patients received special vaccines and immune cells designed to attack the tumor. The study was small (11 particip…
Phase 1 • Sponsor: University of Florida • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
-
New pill could ease neck dystonia symptoms
Symptom relief Stopped earlyThis study tests an experimental oral medication, MTR-601, for people with cervical dystonia, a condition causing painful neck muscle spasms and abnormal head posture. About 80 adults will receive either the drug or a placebo for 8 weeks to see if it safely reduces symptoms. The …
Phase 2 • Sponsor: Motric Bio • Aim: Symptom relief
Last updated Sep 19, 2026 00:00 UTC
-
Can gentle electrical pulses reawaken hand movement after stroke?
Symptom relief Stopped earlyThis trial tests different settings of a gentle electrical stimulation device, placed on the skin of the affected arm, to see which ones best improve hand function in people who have had a stroke. Participants will receive varying durations and strengths of stimulation, and resea…
Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated Aug 22, 2026 00:00 UTC
-
Can a synthetic cannabinoid calm agitation in frontotemporal dementia?
Symptom relief Stopped earlyThis phase 2 trial tests whether nabilone, a synthetic cannabinoid, can reduce agitation in people with frontotemporal dementia (FTD). Participants receive both nabilone and a placebo in random order to compare effects. The study includes adults with behavioral variant FTD or pri…
Phase 2 • Sponsor: Simon Ducharme, MD • Aim: Symptom relief
Last updated Jul 30, 2026 00:00 UTC
-
New radiation technique aims to calm tremors without surgery
Symptom relief Stopped earlyThis study tested a new way to treat hand tremors caused by essential tremor or Parkinson's disease using a linear accelerator, a common radiation machine. Instead of one large dose, the radiation was given in three smaller sessions to protect healthy brain tissue. The goal was t…
Phase 2 • Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
-
Experimental drug aims to curb disinhibition in dementia patients
Symptom relief Stopped earlyThis study tested a drug called AVP-786 to see if it could safely reduce disinhibition—impulsive or inappropriate behavior—in people with neurodegenerative disorders like Alzheimer's or frontotemporal dementia. The trial planned to include many participants but was terminated ear…
Phase 2 • Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 12:32 UTC
-
Brain pacemaker tested for uncontrollable tics
Symptom relief Stopped earlyThis study tested whether deep brain stimulation (DBS) could help people with severe Tourette syndrome whose symptoms don't improve with medication. Researchers placed tiny electrodes in a part of the brain called the thalamus to try to calm abnormal signals that cause tics. Only…
Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
-
Scientists probe Brain's consciousness switch during anesthesia
Knowledge-focused Stopped earlyThis study looked at how anesthesia changes brain activity in people with Parkinson's disease or essential tremor who were already scheduled for deep brain stimulation (DBS) surgery. Researchers recorded brain signals during a short period of anesthesia to understand which circui…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
-
Scientists probe hidden danger of low blood sugar in diabetes
Knowledge-focused Stopped earlyThis study looked at why people with type 1 diabetes often fail to sense dangerously low blood sugar (hypoglycemia). Researchers tested how opioid drugs like morphine and naloxone affect the body's ability to respond to low sugar. The goal was to better understand the problem, no…
Phase 2 • Sponsor: Albert Einstein College of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
-
3D scans reveal hidden Muscle's role in twisted neck disorder
Knowledge-focused Stopped earlyThis study looked at how a small neck muscle called the obliquus capitis inferior (OCI) contributes to abnormal head rotation in cervical dystonia. Researchers used 3D CT scans to measure muscle function before and after botulinum toxin injections in 21 adults. The goal was to be…
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC