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New radiation technique aims to calm tremors without surgery

NCT ID NCT04727658

Symptom relief Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new way to treat hand tremors caused by essential tremor or Parkinson's disease using a linear accelerator, a common radiation machine. Instead of one large dose, the radiation was given in three smaller sessions to protect healthy brain tissue. The goal was to see if this approach is safe and can reduce tremors without needing an invasive head frame or traveling to a special Gamma Knife center. The study was stopped early after enrolling 9 participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

9 people

The number who actually took part.

Started

Jul 2021

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patient with disabling essential tremor, dystonic and / or parkinsonian in one or more limbs superiors ; * patient contraindicated or refusing deep brain stimulation ; * patient ≥ 18 years old, * women of childbearing potential must take effective contraception ; * signature of informed consent ; p- atients who benefited from contralateral thalami c stimulation can be included in the study Exclusion Criteria: * brain irradiation history ; * contraindication or inability to perform injected MRI ; * life expectancy \<12 months ; * claustrophobic patient who cannot stand the radiotherapy mask ; * abnormal anatomy of the thalamic region ; * treatment with a trial drug within 30 days of entering the study ; * presence of medical, psychological, social or geographic factors likely to modify the patient's compliance with the protocol under study or the monitoring or signing of the consent

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Conditions

The condition(s) this trial relates to.

essential tremor parkinsonian disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Essential tremor Parkinsonian disorders

Contacts and locations

Locations

  • Centre Hospitalier Princesse Grace

    Monaco, 98000, Monaco

More trials for these conditions

Other studies related to the condition(s) this trial covers.