Mixed anxiety and depressive disorder

This study in Zimbabwe will screen women of childbearing age and high school students for HPV and Hepatitis B, then offer vaccines to those who are eligible. It also includes cognitive behavioral therapy for mental health issues. The goal is to see if this combined approach can p…

This study tests whether an AI-informed peer-mentoring program can help healthy teens and young adults (ages 12-25) manage stress and build social skills, lowering their risk of developing anxiety or depression. Researchers will compare this program to standard mentoring and heal…

This trial tests whether an AI-enhanced mobile app called e-CAMP can improve mental well-being and reduce mild-to-moderate depression and anxiety in young adolescents aged 11 to 15. About 300 students from eight schools in Hong Kong will either use the app regularly for eight wee…

This study tests whether an 8-week program of yoga and meditation delivered through a mobile app can reduce anxiety in adults with stable rheumatoid arthritis. About 100 participants will either use the app daily or continue with standard care. Researchers will measure changes in…

This study tests an 8-week group program that combines mindfulness, gentle movement, breathing exercises, healthy eating tips, and art activities for adults aged 55 and older with mild-to-moderate depression or loneliness. The goal is to see if the program improves mood, reduces …

This study will test an internet-based therapy program for people with emotional disorders like depression and anxiety. The program teaches skills to manage emotions and is designed to be used at home. Researchers want to see if it works well in primary care settings, if it is co…

This study tests a program called REWIRE for teens aged 12-17 who feel anxious or depressed and use social media over 3 hours daily. The program aims to cut social media use by about half and replace it with positive offline activities like hobbies or time with friends. Researche…

This study tests a safe, non-invasive therapy that uses gentle pressure on the arms to improve sleep and mood in people who have had a stroke and suffer from insomnia. The treatment, called remote ischemic adaptation, aims to help the brain recover by briefly restricting and rest…

This study tests whether adding virtual reality (VR) sessions to standard counseling helps university students with public speaking anxiety more than counseling alone. About 72 students will be randomly assigned to either counseling only or counseling plus VR exercises that simul…

This study tests whether a version of dialectical behavior therapy (DBT) that has been adapted to fit local cultures can help adults aged 18-45 with borderline personality disorder better manage their emotions and reduce self-harm. The therapy is being studied in a low- and middl…

This study tests whether acupuncture can reduce anxiety and depression in women with breast cancer. Researchers will compare real electroacupuncture to a sham version in 360 participants. The goal is to see if this needle-based therapy improves emotional well-being without medica…

This study will test whether taking a break from digital devices and social media can help reduce depression, anxiety, stress, and improve sleep quality in young adults. One hundred participants who use social media at least 8 hours a day will be randomly assigned to a digital de…

This study compares an AI-powered orientation program to one given by human nurses for patients in the intensive care unit (ICU). The goal is to see if the AI program helps patients have more days without delirium, lowers anxiety and depression, and shortens their hospital stay. …

This study will enroll 500 adults with high levels of repetitive negative thinking (like worry or rumination) to understand why cognitive-behavioral therapy helps. Participants will receive one of two digital therapy programs: one focusing on concrete thinking, the other on self-…

This study follows 120 people with laryngeal cancer to see how their quality of life, voice, swallowing, pain, and mood change before treatment and at 3, 6, and 12 months after. Researchers will use questionnaires to track these changes. The goal is to better understand recovery …

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…