Zimbabwe study targets cancer prevention with vaccines and mental health care
NCT ID NCT06786429
First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 3 times
Summary
This study in Zimbabwe will screen women of childbearing age and high school students for HPV and Hepatitis B, then offer vaccines to those who are eligible. It also includes cognitive behavioral therapy for mental health issues. The goal is to see if this combined approach can prevent cervical and liver cancers in these groups.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Gardasil 9 vaccine, Hepatitis B Virus Vaccine (HBV), Cognitive Behavioral Therapy
- What this could lead to
- If successful, this approach could reduce cervical and liver cancer rates in Zimbabwe by combining vaccination, screening, and mental health support.
- What could go wrong
- This is an observational study with a large sample, but it does not test a new treatment. Results may not apply to other regions, and vaccine uptake or follow-up may be limited.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 2,140 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2027
An estimate. Start dates often move.
- Expected to finish
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Dec 2032
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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13 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * For the High school students' group: All students aged 13 years and older, enrolled at the selected Mtshabezi and Matopo High Schools in the Gwanda and Matobo Rural Districts during the five years of the project, are eligible to participate in the study. Ability to understand and respond to questions on the Youth Risk Behavior Survey questionnaire and PHQ-9 scale. Relevant history of HPV vaccine administration. Ability to obtain parental/guardian consent for participation. \- For the women's group: All women and young female adults, thirteen to fifty years old, and requesting health services for prenatal, post-partum, family planning, and other care during the five-year project period are eligible to participate. Can understand and respond to the PHQ-9 and Edinburgh Postnatal Depression scales. Must have a valid consent for participation in the study. Exclusion Criteria: * males who are not enrolled in these participating High Schools. * children below the age of thirteen who are not enrolled in high schools and are not seeking prenatal, post-partum, and family planning services at these selected health facilities during the project period. * Any eligible potential participant without a valid consent. * Any potential participant who is excluded by a doctor or midwife for a known contraindicating medical condition that can lead to potential harm to the participant or staff. Any potential participant who is unable to understand and respond to the questions being asked.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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