Metastatic malignant neoplasm in the spinal cord

This study will follow 130 people who had surgery for cancer that spread to the spine. Half will get radiation after surgery, half will not. Researchers want to see if radiation helps keep the cancer from coming back and improves how long patients live. The goal is to help doctor…

Researchers are testing stereotactic body radiation therapy (SBRT) in adults whose cancer has spread to the spine and is pressing on the spinal cord. SBRT delivers high doses of radiation precisely to the tumor while limiting damage to nearby tissue. The trial enrolls 50 particip…

This study looks at whether high-precision radiation therapy, delivered by the Edge system, can improve outcomes for people with spinal metastases from solid tumors. After surgery to relieve pressure on the spinal cord, patients receive radiation in five sessions to target remain…

This trial is testing whether giving radiation in two separate doses works better than a single high dose for people with cancer that has spread to the spine. The goal is to see which approach controls tumor growth longer while keeping side effects low. About 274 adults with up t…

This pilot study is testing a precise form of radiation called proton SBRT for people with cancer that has spread to the spine and cannot be treated effectively with standard photon radiation. The study will enroll 12 participants and aims to see if the treatment can be delivered…

This early-stage study is testing the safety of two devices (NovoTTF-200M and NovoTTF-200A) that deliver electric fields to treat spinal tumors that have not responded to standard treatments like surgery or radiation. About 30 participants will receive the treatment, either alone…

This study is for people with cancer that has spread to the spine. It tests whether adding a procedure called vertebroplasty (which repairs broken spine bones) to standard radiation and immunotherapy can help prevent fractures and improve survival. About 200 participants will rec…

This study is testing whether giving an extra 'boost' of radiation to spinal tumors that have spread from other cancers can better control the tumor, reduce pain, and limit side effects. The trial will enroll 108 adults with confirmed or suspected solid tumors that have spread to…

This study is testing a highly precise radiation method called SBRT for people with cancer that has spread to the spine. The goal is to deliver strong radiation doses while protecting nearby healthy tissue. Researchers will track side effects and how well the treatment controls t…

This study compares carbon fiber and titanium screws in people with cancer that has spread to the spine. The goal is to see if carbon screws cause fewer imaging problems, making it easier to plan radiation therapy and spot cancer return. About 226 adults will take part, and the s…

This study tests whether having spine surgery and radiation on the same day helps people with painful spinal tumors recover physical function faster than the usual approach of surgery followed by radiation weeks later. About 100 adults with unstable spinal metastases will be rand…

This study tests whether combining three treatments—kyphoplasty (spine stabilization), radiofrequency ablation (heat to destroy tumor tissue), and standard radiation—can better reduce pain from spine tumors. About 70 adults with cancer that has spread to the middle or lower back …

This study tests a new way to give radiation to people with cancer that has spread to the spine and is pressing on the spinal cord. The goal is to see if giving a slightly higher dose of radiation to the tumor while protecting the spinal cord is safe. About 60 adults with this co…

This study tests whether using an MRI machine to guide radiotherapy can treat metastatic spinal cord compression in a single one-hour appointment, instead of the usual two visits (a planning CT scan then radiotherapy). About 72 adults with confirmed spinal cord compression will b…

This study tests a new way to deliver radiation to spine tumors that have spread from other cancers. Instead of the usual 1-2 high-dose sessions, the radiation is given in 5 smaller doses over several days, which may reduce side effects. The trial will enroll 60 adults with spine…

This study compares three types of radiation therapy for cancer that has spread to the spine, with the goal of relieving pain. About 240 participants will be randomly assigned to receive either standard external beam radiation, standard-dose stereotactic body radiation, or higher…

This study observes 100 adults with painful spinal metastases to see how doctors choose between two radiation types: standard palliative radiation (CRT) and a more precise, high-dose form (SBRT). Researchers will track pain relief, tumor control, and the reasons behind treatment …