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Extra radiation boost may help control spine tumors and ease pain

NCT ID NCT07478289

Disease control Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether giving an extra 'boost' of radiation to spinal tumors that have spread from other cancers can better control the tumor, reduce pain, and limit side effects. The trial will enroll 108 adults with confirmed or suspected solid tumors that have spread to the spine. Participants will receive standard spine radiation plus an additional dose tailored to their treatment plan.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Radiation boost (additional dose of radiation to the spine)
What this could lead to
If successful, this approach could improve long-term tumor control and reduce pain for people with spinal metastases, offering a more effective treatment option.
What could go wrong
This is a mid-stage trial with only 108 participants, so results may not apply to everyone. The extra radiation could increase side effects, and it is not yet known if it will meaningfully improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 108 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Dec 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histopathologically confirmed solid tumor malignancy, or strong suspicion based on clinical and radiographic examination of malignancy * Spinal metastases with paraspinal disease extension documented with MRI and recommended for treatment with SBRT * Post-operative SBRT is permitted (after stabilization and/or decompression surgery) as long as no prior radiotherapy had been delivered to the spinal level planned for trial treatment and paraspinal disease is present * ECOG performance status 0-2 * Able to tolerate protocol SBRT * Age 18 years or older * Patient is able and willing to complete the Patient Diary (pain and analgesic use) * Consent must be appropriately obtained in accordance with local requirements. Each patient must sign a consent form prior to enrollment in the trial to document their willingness to participate * Patients must be accessible for treatment and follow-up * Treatment to begin within 14 days (ideally 7 days) of radiotherapy simulation Exclusion Criteria: * Extremely radiosensitive histology (seminoma, small cell lung cancer, hematologic primaries) * Prior radiotherapy in the spine target of interest * Spinal instability as assessed by the Spinal Instability Neoplastic Score with a score of \> 12 * Symptomatic cord compression or cauda equine syndrome resulting from bony compression or epidural compression of the spinal cord and cauda equina, respectively. Symptomatic refers to neurologic deficit in the form of motor, bowel or bladder dysfunction * Pacemaker, such that MRI cannot be performed or treatment cannot be delivered safely * Cytotoxic chemotherapy within 1 week prior to radiotherapy delivery

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Conditions

The condition(s) this trial relates to.

metastatic malignant neoplasm in the spinal cord

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spine metastasis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sunnybrook Health Sciences Centre

    RECRUITING

    Toronto, Ontario, M4N3M5, Canada

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