Metastatic malignant neoplasm in the lymph nodes

Researchers compare two ways to manage the neck in people with early oral squamous cell carcinoma, a cancer that has not spread to lymph nodes. One group has surgery to remove the primary tumor only, then regular checkups with imaging to watch for lymph node spread. The other gro…

This trial is testing a device that uses electrical pulses to destroy cancer cells in neck lymph nodes of people with thyroid cancer that has come back after surgery. About 85 participants will receive one or two treatments under ultrasound guidance. The main goal is to see how m…

This early-phase study tests a new radioactive drug called NRT6008, given alongside standard chemotherapy, for people with advanced pancreatic cancer that cannot be removed by surgery or has spread to nearby lymph nodes. The trial will enroll 58 adults to find the safest dose and…

This study tests a new type of radiation therapy for men with prostate cancer that has spread to lymph nodes in the abdomen or pelvis. The treatment uses daily CT scans to adjust the radiation beam precisely to the tumor and nearby at-risk areas. The goal is to control the cancer…

This study tests a way to give radiation therapy for cancer that has spread to lymph nodes in the belly or pelvis. Normally, patients need 5 sessions of a precise type of radiation called SBRT. This study uses daily scans to adjust the radiation beam, which may allow some patient…

This study compares two surgical approaches for papillary thyroid cancer that has spread to lymph nodes in the neck: robotic surgery through the armpit versus traditional open surgery. The goal is to see if the robotic method offers similar cancer control and survival rates while…

Researchers compare two tracers, indocyanine green (ICG) and blue patent dye, for locating lymph nodes during targeted axillary dissection in breast cancer patients who have received chemotherapy before surgery. The trial measures how often each tracer successfully identifies the…

This study is testing a new blood test called TuFEst that uses DNA fragments and deep learning to stage breast cancer and check if it has spread to lymph nodes. Researchers will enroll 269 breast cancer patients, including those having surgery and those receiving chemotherapy bef…

This study tests if a safe green dye (indocyanine green) can help surgeons find lymph nodes that might contain cancer during a mastectomy, without needing a separate cut under the arm. About 90 women with early-stage breast cancer will receive the dye and a standard radioactive t…

This study compares three methods for reading CT and MRI scans of lymph nodes to see which best detects cancer. The new method, LN-RADS, may find small metastases that current guidelines miss. Researchers will enroll 1,000 people with known or suspected cancer who need a lymph no…

This study is developing an artificial intelligence (AI) model to detect whether cancer has spread to lymph nodes by analyzing digital images of tissue slides. Researchers will compare the AI's accuracy to that of pathologists using slides from 10,000 cancer patients. The goal is…

This study tests a new type of ultrasound called super-resolution ultrasound (SRUS) to see if it can better tell the difference between benign (non-cancerous) and malignant (cancerous) swollen lymph nodes. About 779 adults with abnormal lymph nodes will receive an injection of ul…

This study is auditing a surgical technique called Targeted Sentinel Node Biopsy (TSNB) for breast cancer patients who have a small number of cancer cells in their lymph nodes. The goal is to see if this less invasive procedure can accurately identify cancer spread while causing …

This study looks at whether a blood test can find tiny bits of tumor DNA left after breast cancer surgery. It includes 100 women with early-stage breast cancer that spread to 1-3 lymph nodes. The goal is to see if this test can help predict which patients are more likely to have …

This study tests two navigation systems—3D Slicer and Siemens Monaco—to help surgeons locate and remove abnormal lymph nodes during urologic cancer surgery. The goal is to see if these image-guided tools make the procedure simpler and more precise. Twenty adults with suspected or…

This study aims to help Dutch hospitals switch from using a radioactive tracer to a green dye called indocyanine green (ICG) to find the first lymph node that breast cancer may spread to. The dye is given during surgery, avoids radiation, and requires no extra hospital visits. Re…

This study tests a standardized technique for finding lymph nodes in lung tissue removed during surgery. Researchers want to see if this method finds more nodes and improves cancer staging. About 160 adults with lung cancer who are having a lobectomy will take part. The goal is t…

This study looks at whether regular groin ultrasound scans can safely replace surgery to check for cancer spread in women with early-stage vulvar cancer. About 30 women will be randomly assigned to either have groin surgery or get ultrasound checks every 2 months for a year. The …

This study is creating an artificial intelligence (AI) model that uses MRI scans and tissue samples to predict whether high-risk prostate cancer has spread to nearby lymph nodes. The goal is to help doctors make better treatment decisions without needing extra invasive tests. Abo…