New scan method could catch 20% more hidden cancers
NCT ID NCT06527027
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares three methods for reading CT and MRI scans of lymph nodes to see which best detects cancer. The new method, LN-RADS, may find small metastases that current guidelines miss. Researchers will enroll 1,000 people with known or suspected cancer who need a lymph node biopsy. The goal is to see if LN-RADS is more accurate than the standard RECIST 1.1 and the newer Node-RADS systems.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If LN-RADS works better, doctors could detect more lymph node metastases, leading to more accurate cancer staging and better treatment decisions.
- What could go wrong
- This is a diagnostic comparison study, not a treatment trial. Even if LN-RADS is more accurate, it may not improve patient outcomes or be adopted widely.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 1,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2023
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * diagnosed or suspected cancer, * planned lymph node biopsy or lymphadenectomy, * planned or performed CT/MRI covering an area of the body with lymph nodes, - verified histopathologically or cytologically, * informed consent to participate in the study. Exclusion Criteria: * non-diagnostic CT/MRI images of lymph nodes due to reasons such as movement artifacts, artifacts from metal elements and any other factors that do not allow for proper assessment of the nodes, * inconclusive histopathological or cytological results, which do not allow the nodes to be classified into one of two groups - benign or malignant.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Copernicus Memorial Hospital
RECRUITINGLodz, 93-513, Poland
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Doradztwo i Zarządzanie w Opiece Zdrowotnej A.K. Sp.z o.o
ACTIVE_NOT_RECRUITINGWarsaw, Poland
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Independent Public Healthcare Centre (SPZOZ) , University Clinical Hospital No. 2 of the Medical University of Łódź
ACTIVE_NOT_RECRUITINGLodz, Poland
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Maria Skłodowska-Curie National Research Institute of Oncology - National Research Institute
ACTIVE_NOT_RECRUITINGKrakow, Poland
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Maria Skłodowska-Curie National Research Institute of Oncology - National Research Institute
ACTIVE_NOT_RECRUITINGWarsaw, Poland
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Professor Orłowski Hospital in Warsaw , Independent Public Healthcare Centre
ACTIVE_NOT_RECRUITINGWarsaw, Poland
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