Metastatic carcinoma in the bone

This study tests whether two common heart medications—atorvastatin (a statin) and lisinopril (an ACE inhibitor)—can prevent or reduce heart damage caused by radiation therapy for chest cancers like breast, lung, and esophageal cancer. About 60 adults receiving chest radiation wil…

This phase 2 trial tests whether adding the drug narlumosbart and precise radiation therapy to standard first-line treatment can help people with advanced non-small cell lung cancer that has spread to the bones. The study will enroll 27 adults who have not had prior systemic ther…

This phase 2 trial tests a new drug called zanzalintinib, taken as a pill, combined with a bone-strengthening agent for people with advanced kidney cancer that has spread to the bones. The study enrolls 20 participants whose cancer has worsened after 1–3 prior treatments, includi…

This trial compares two surgical methods for reattaching the hip abductor muscles after proximal femur replacement, a surgery often needed for bone cancer or metastases. The goal is to see which method leads to better walking and hip function. Researchers will also test a simple …

This study looks at two types of hip surgery for people whose cancer has spread to the hip bone. One surgery removes the damaged bone and replaces it with an artificial joint. The other uses metal rods and plates to hold the bone together. The goal is to see which surgery leads t…

This study combines two treatments—laser heat to destroy tumors near the spinal cord and precise radiation—to better control spine tumors that have spread from other cancers. About 60 adults with solid tumors will receive both therapies. The goal is to improve tumor control, redu…

This early-stage trial is testing a new drug called SKB107 in people with advanced solid tumors that have spread to the bones. The drug delivers a small amount of radiation directly to bone tumors. The study will enroll about 90 adults to check if the drug is safe, how it moves t…

This study tests whether using a smaller, more precise radiation target for spinal tumors can control cancer just as well as treating the whole vertebra. One hundred adults with spine metastases will be randomly assigned to standard or smaller-target radiation. The goal is to see…

This study is testing a highly precise radiation method called SBRT for people with cancer that has spread to the spine. The goal is to deliver strong radiation doses while protecting nearby healthy tissue. Researchers will track side effects and how well the treatment controls t…

This study tests whether giving radiation early to spine tumors that are not yet painful can prevent serious problems like fractures or spinal cord compression. About 74 adults with cancer that has spread to the spine will receive radiation before symptoms get worse. The goal is …

This study tests whether giving radiotherapy early to high-risk bone metastases that are not yet causing symptoms can prevent future bone complications like fractures. About 120 adults with solid tumors and at least three bone metastases will be randomly assigned to either standa…

This study is tracking 50 people with cancer that has spread to the bones (bone metastases) to see if freezing those tumors with a special probe (cryoablation) can control them. The goal is to prevent local tumor growth, ease pain, and improve quality of life. Participants have l…

This study tests a new injection called SHR-2017 in 210 adults with solid tumors that have spread to their bones. The goal is to see if it can prevent bone complications like fractures and pain, compared to an existing drug (denosumab). Participants will receive either high or lo…

This study compares carbon fiber and titanium screws in people with cancer that has spread to the spine. The goal is to see if carbon screws cause fewer imaging problems, making it easier to plan radiation therapy and spot cancer return. About 226 adults will take part, and the s…

This study is testing whether using radiofrequency ablation (heat to kill cancer cells) plus bone cement to stabilize the spine, followed by radiation, works better than radiation alone for people with cancer that has spread to the spine. The goal is to see if the combination red…

This master trial is testing a new radiation technique called SMART, which uses MRI to guide and adapt radiation beams in real time. The goal is to deliver high doses precisely to tumors while protecting nearby organs. The study enrolls adults with various cancers (pancreas, lung…

This study aims to develop a blood test that detects RNA from tiny particles (exosomes) to predict if prostate cancer has spread to the bones. Researchers will analyze blood samples from 1,000 men with newly diagnosed prostate cancer and compare results with PSMA PET scans. The g…

This trial is testing whether adding a procedure called vertebroplasty—where bone cement is injected into a weakened vertebra—before standard radiation therapy can provide faster and better pain relief for people with spine metastases. Participants will either receive radiation a…

This study is looking at whether combining two treatments — a minimally invasive procedure called percutaneous ablation and standard radiation therapy — can better relieve pain from bone cancer that has spread. Researchers will follow 120 people whose pain is not controlled by me…

This study tests whether a single, quick radiation session can treat painful bone metastases without the usual planning visit. About 40 adults with cancer and one or two painful bone spots will get one dose of radiation in a single trip to the hospital. The goal is to see if this…

This early-phase trial is testing whether a minimally invasive procedure using special light-activated nails can help stabilize the pelvis in people whose cancer has spread to the bone around the hip socket. Fifty adults with confirmed cancer and visible pelvic metastases will be…

This phase 3 trial tests whether a precise, high-dose radiation technique (SBRT) provides better pain relief than standard radiation for cancer patients with painful bone metastases not in the spine. About 230 adults with solid tumors and moderate to severe pain will be randomly …

This study tests whether giving spine radiation in one session or two sessions better prevents bone fractures in people with cancer that has spread to the spine. About 130 adults with spine tumors will receive either one or two focused radiation treatments. The goal is to find wh…

This study tests whether a very low dose of radiation (2 Gy) can relieve bone pain in people with multiple myeloma that has spread to the bones. The goal is to see if this gentler approach works as well as standard radiation but with fewer side effects and less disruption to chem…

This phase 2 trial tests whether a higher dose of radiation (40-50 Gy over 10 sessions) can better relieve pain from cancer that has spread to bones or other areas. Researchers hope to double the complete pain response rate at one month compared to standard doses. The study invol…

This early-phase study tests a single dose of TLX090-Tx, a radioactive drug, in 33 adults with advanced cancer that has spread to the bones and causes pain. The goal is to find a safe dose and see if it can reduce pain. Participants must have at least one painful bone spot and ha…

This study tests whether offering a palliative care consultation early—when patients with advanced cancer and bone metastases start radiotherapy—improves their satisfaction with care and quality of life. About 246 participants will be randomly assigned to receive either a tailore…

This study looks at whether a procedure called arterial embolization can reduce pain and improve quality of life in people with bone metastases (cancer that has spread to the bones). The procedure blocks blood flow to the tumor, which may shrink it and ease symptoms. Researchers …

This study tests whether adding a non-opioid painkiller (ketorolac) to standard opioid pain medication can reduce the amount of opioids needed after preventive femur surgery. The study includes 60 adults with bone lesions from cancer who are getting a metal rod placed in the thig…

This study tests whether adding cryoablation (a procedure that freezes and kills cancer cells) to standard radiation therapy provides better pain relief for people whose cancer has spread to their bones. About 40 participants with various cancers will be split into two groups: on…

This study tests a procedure that uses radiofrequency heat to destroy spine tumors, followed by bone cement to stabilize the spine. Sixteen people with cancer that has spread to the spine will receive the treatment. The goal is to see if the tumors become less active on PET scans…

This study tests a newer, more precise radiation method called SBRT against standard radiation to see which better relieves pain from cancer that has spread to the bones. About 220 adults with solid tumors or multiple myeloma and pain at the treatment site will take part. The goa…

This study tests a new way to deliver radiation to spine tumors that have spread from other cancers. Instead of the usual 1-2 high-dose sessions, the radiation is given in 5 smaller doses over several days, which may reduce side effects. The trial will enroll 60 adults with spine…

This study looks at whether reducing the amount of spine radiated for painful bone metastases can still effectively relieve pain while possibly causing fewer side effects. About 600 people with spinal bone metastases will be randomly assigned to receive either standard radiation …

This study tests a new way to plan radioactive seed implants for people with cancer that has spread to the bones. The new method uses a computer model to help doctors place the seeds more precisely, aiming to improve pain relief and lower the risk of bone fractures or seeds movin…

This study will collect data from 2,000 patients in the Netherlands and France who are receiving standard, minimally invasive cancer treatments like tumor ablation or catheter-based therapies for liver, lung, kidney, or bone cancers. During these procedures, a special CT scanner …

This study collects health information from 500 adults with painful bone metastases that have spread from other cancers. Researchers aim to better understand the disease and track survival over time. No new treatments are given; participants simply share their medical data.

This study is following 3,000 adults with spine tumors (either primary or that have spread from elsewhere) who undergo surgery to relieve pressure on the spine, followed by radiation. Researchers are tracking how long patients live, whether the tumor stays under control, and how …

This study looks at men with advanced prostate cancer that has spread to the bones. Researchers want to see if certain DNA repair problems in the cancer cells make the drug radium-223 work better or worse. The goal is to help doctors choose the best treatment for each patient in …

This study is testing whether a smartwatch can track changes in walking and daily activities in people with bone cancer (osteosarcoma or metastatic bone disease). The goal is to see if the watch can help doctors spot problems early and personalize care. About 60 participants will…

This study collects tissue and blood samples from 1,500 people with prostate or bladder cancer that has come back or spread. Researchers will analyze the samples to find genetic changes and other markers that may explain why some cancers stop responding to treatment. The goal is …

This study looks back at 600 patients who had surgery for a broken or about-to-break upper thigh bone caused by cancer that spread from elsewhere. Researchers will compare two surgical methods—a metal rod inside the bone or a replacement joint—to see which one leads to fewer comp…

This study will follow 2500 cancer patients with bone metastases to better understand why some respond to radiation therapy and others do not. Researchers will collect data to build tools that predict pain relief and survival, and to create a platform for testing new treatments. …

Researchers are gathering medical records, scans, and lab results from 250 patients with bone metastases that spread from other cancers. They will use this data to create a dataset called RAW, which will help develop computer models to predict fracture risk and life expectancy. T…