Malignant glioma

This pilot trial asks whether removing a wider margin of brain tissue around a high-grade glioma—beyond the standard visible tumor boundary—can improve survival without causing more neurological harm. It enrolls adults with a first-time diagnosis of high-grade glioma in a surgica…

This trial asks whether it is safe to shorten the total treatment time for people with newly diagnosed high-grade gliomas, a type of aggressive brain tumor. The usual plan is laser surgery followed by radiation and chemotherapy, taking about 10 weeks. The study tests starting rad…

This phase 1 study tested a drug called D2C7-IT in 81 adults with recurrent malignant glioma (a type of brain tumor). The drug is a lab-made antibody linked to a toxin that targets specific proteins on tumor cells. It was infused directly into the tumor over 72 hours using thin t…

This pilot study tested a new approach for patients with recurrent high-grade glioma (grade 3 or 4 brain tumors) who have few options left. Researchers used a radioactive drug called 177Lu-PSMA to deliver radiation directly to tumor cells, after first checking if the tumors take …

This early-phase trial tested a new drug called obitazidine (SM-1) combined with the chemotherapy temozolomide in 35 adults with recurrent high-grade gliomas, a type of aggressive brain cancer. The main goal was to find a safe dose and check for side effects, while also looking f…

This early-phase study tested whether adding the experimental drug ruxolitinib to standard radiation and chemotherapy (temozolomide) is safe for people with newly diagnosed high-grade gliomas or glioblastoma. Ruxolitinib targets proteins that help cancer cells grow. The study enr…

This study tested a special vaccine made from the child's own immune cells (dendritic cells) to fight aggressive brain tumors like high-grade glioma and DIPG. Ten children received the vaccine alongside standard treatments. The goal was to see if the vaccine was safe, possible to…

This phase 2 trial tested the drug samotolisib in 18 children and young adults with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that had spread, returned, or stopped responding to treatment. Only patients whose tumors had specific mutations in the TSC or…

This early-phase study tested whether pumping the chemotherapy drug topotecan directly into the brain is safe for people with recurrent high-grade gliomas (aggressive brain tumors). Only 5 patients took part, and the main goal was to find a safe dose. The drug was delivered conti…

This phase 2 trial tested whether adding two immunotherapy drugs (nivolumab and ipilimumab) to standard chemotherapy (temozolomide) improves survival in 47 adults with newly diagnosed glioblastoma or gliosarcoma. Participants had their tumors surgically removed and completed init…

This small study tested whether a device using focused ultrasound can safely open the blood-brain barrier in patients with high-grade glioma (a type of aggressive brain cancer). The goal was to allow standard chemotherapy to reach the tumor more effectively. Only 3 patients were …

This small pilot study tested whether combining focused ultrasound with a second round of radiation is safe for people with recurrent glioblastoma, an aggressive brain cancer. Seven adults who had already tried standard treatments received the combination therapy. The goal was to…

This study tested whether a device called ExAblate, which uses focused ultrasound, can safely open the blood-brain barrier in 20 people with high-grade glioma (a type of brain cancer). The goal was to allow standard chemotherapy to reach the tumor more effectively. Researchers ch…

This early-phase trial tested a combination of two drugs—fluvastatin (a cholesterol-lowering statin) and celecoxib (an arthritis drug)—in 20 children and young adults with certain brain tumors (gliomas) that had come back or not responded to treatment. The goal was to find the sa…

This early-phase trial tested a new treatment for aggressive brain tumors called high-grade glioma. Sixteen patients received a drug (5-ALA) plus focused ultrasound to activate the drug inside the tumor, a few days before standard surgery and chemo-radiation. The main goal was to…

This early-phase study tested an experimental drug called INCB7839 in 13 children whose high-grade gliomas (aggressive brain tumors) had come back or worsened after standard treatment. The main goals were to find a safe dose and check for side effects. The drug works by blocking …

This phase 2 trial tested a combination of two drugs (retifanlimab and epacadostat) plus radiation and bevacizumab in 51 patients with recurrent glioblastoma, an aggressive brain cancer. The goal was to boost the immune system's attack on the tumor and improve survival. The study…

This study tested whether adding whole brain radiation and a drug called plerixafor to the usual chemotherapy and radiation could help people with a fast-growing brain tumor called glioblastoma. 21 patients took part. The goal was to see if the combination could delay tumor growt…

This phase 1 trial tested a combination of two drugs, ASP8374 and cemiplimab (Libtayo), in 14 people with recurrent malignant glioma, a type of brain cancer. The study had two parts: first, finding the safest dose of ASP8374 when given with cemiplimab, and second, checking how th…

This study tested the drug lenvatinib in 127 children, adolescents, and young adults whose solid tumors had come back or stopped responding to treatment. The goal was to see if the drug could shrink tumors and to check for side effects. Participants received lenvatinib daily, and…

This phase 2 study tested the drug olaparib in 35 people with recurrent IDH-mutant high-grade gliomas, a type of brain tumor. The goal was to see if olaparib could stop the tumor from growing for at least 6 months. Participants took olaparib tablets twice daily until their diseas…

This study looked at whether a special PET scan using 18F-FDOPA can help doctors make better treatment decisions for people with brain tumors (gliomas or metastases) when standard MRI results are unclear. 85 patients whose MRI scans were inconclusive received this PET scan, and r…

This study tested a special PET scan tracer called FLT in 50 adults with brain tumors (gliomas or metastases). The goal was to see if FLT-PET can measure how fast tumor cells are growing, which could help doctors diagnose and predict tumor behavior better than current scans like …

This study tested whether a special dye called fluoroethyltyrosine (FET) can improve PET scans for detecting brain tumors that have come back. 143 people with suspected recurrent brain tumors received an injection of FET before their PET scan. The goal was to see if FET-PET could…

This early study tested a special light probe that helps surgeons see brain tumor tissue during an operation. Eleven adults with suspected brain tumors took part. The probe uses a drug that makes tumor cells glow, and the goal was to see if the device could accurately tell tumor …

This pilot study tested a new way to deliver radiation therapy to people with recurrent IDH-mutant gliomas who had already received radiation to the brain. Instead of giving one large dose, the radiation was given in many small, timed pulses to reduce side effects. The study incl…

This pilot trial explores whether using a tumor's molecular profile—its gene expression and DNA sequencing—can help doctors choose a personalized treatment plan for children and young adults with high-grade glioma (a type of brain cancer). Participants receive a recommendation fr…

This study tested whether an 18F-FDOPA PET scan changes treatment decisions for people with high-grade gliomas (aggressive brain tumors) when standard MRI results are unclear. Researchers enrolled 110 patients and compared treatment plans before and after the scan. The goal was t…

This study looked back at medical records of 41 patients who had surgery for aggressive brain tumors (high-grade gliomas). Some surgeries used fluorescent dyes that make tumor tissue glow, helping surgeons tell it apart from healthy brain. The goal was to see if using these dyes …

This study looked at whether a special PET scan (18F-DOPA) can help doctors better see brain tumors when planning radiation therapy. 91 adults with newly diagnosed gliomas were enrolled. The goal was to see if this scan improves treatment planning and helps predict how well patie…

This study looked at whether a blood test measuring a protein called hPG80 (progastrin) can help track high-grade brain tumors like glioblastoma. Researchers took blood samples from 30 patients before, during, and after radiation and chemotherapy. The goal was to see if hPG80 lev…

This pilot study tested whether a special PET scan using 18F-FDOPA can help doctors better plan surgery and radiation for people with newly diagnosed brain tumors (gliomas). Twenty-four adults took part at Mayo Clinic. The goal was to see if the scan provides useful information b…