Liver and intrahepatic bile duct neoplasm

This study is collecting information on how well the HistoSonics Edison System, which uses sound waves (histotripsy) to destroy liver tumors, works in everyday medical practice. Up to 5,000 adults with liver tumors will be followed for up to 5 years after treatment. The main goal…

This study tests a new treatment called ECT204 for adults with advanced liver cancer that has not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The trial will enroll 60 pe…

This study is testing a treatment called BSJ019T in Japanese patients with liver cancer that cannot be removed by surgery and has not responded to standard treatments. The goal is to see if the treatment can control the cancer's growth and how safe it is. About 51 participants wi…

This study tests a new drug called PF-08634404, given alone or with another drug (ipilimumab), in adults with advanced liver cancer that cannot be surgically removed. The goal is to check safety, side effects, and whether the drug shrinks tumors. About 138 participants will recei…

This trial investigates a new cell therapy called ET140203 T cells for children and young adults (ages 1–21) with certain liver cancers—hepatoblastoma, hepatocellular carcinoma, or related tumors—that have come back or not responded to standard treatment. Participants must have h…

This study is testing a new robotic system that uses just one small incision to perform surgeries on the liver, pancreas, stomach, and esophagus. The goal is to see if this single-port approach is safe and works well for these complex operations. The study will enroll 35 adults w…

This study tests a powerful combination of treatments for people with advanced liver cancer that cannot be surgically removed. The approach uses heat-based ablation to destroy the main tumor, followed by targeted therapy (lenvatinib), immunotherapy (tislelizumab), and a procedure…

This early-stage study tests a new drug called AST-201 in about 70 adults with advanced solid tumors that have a protein called GPC3. The main goal is to check the drug's safety and find the right dose. Researchers will also measure how the drug moves through the body and look fo…

This study tests a procedure called EUS-guided radiofrequency ablation (RFA) for solid tumors in the stomach, liver, kidney, or adrenal glands. It involves using an endoscope to insert a needle that heats and destroys tumor tissue. The study will enroll 30 adults who cannot have …

This study tests a new gel called INT001 that is injected directly into liver tumors to kill them. About 31 adults with liver cancer who cannot have surgery will receive one injection and be followed for 90 days. The goal is to see if the gel safely destroys the tumor and what si…

This study tests whether adding a precise type of radiation (carbon ion radiotherapy) to standard immunotherapy drugs (atezolizumab and bevacizumab) can better control advanced liver cancer. About 52 adults with liver cancer that cannot be surgically removed will receive this com…

This study tests whether contrast-enhanced ultrasound (CEUS) can better detect if liver cancer (HCC) has been killed by radioembolization treatment. Standard CT or MRI scans often take months to show clear results, delaying further treatment. Researchers will enroll 30 patients a…

This study is testing a new ultrasound imaging method called Contrast Enhanced Super-Resolution (CESR) to see if it can better detect and tell apart cancerous and non-cancerous lesions in the breast, liver, and kidney. It involves 40 participants: 10 healthy volunteers to fine-tu…

This study tests whether contrast-enhanced ultrasound (CEUS) can accurately show how well liver tumors respond to a treatment called chemoembolization (TACE). Currently, doctors wait 1-2 months after TACE and use MRI or CT scans to check results. CEUS can be done during the proce…

This trial tests whether a different way of closing the abdominal wall during liver tumor surgery can lower the chance of developing an incisional hernia. 140 patients will be randomly assigned to receive either the new 'short stitch' method or the traditional closure. Researcher…

This study tests whether an accelerated recovery program can safely shorten hospital stays for 36 adults undergoing minimally invasive liver surgery. Participants must have a tumor suitable for a specific type of liver resection, no cirrhosis, and live within 50 miles of the medi…

This study compares two types of anesthesia—spinal and epidural—for people having liver surgery. The goal is to see if spinal anesthesia leads to better blood pressure control, less need for IV fluids, and similar pain relief with faster recovery. About 128 adults undergoing elec…

This study tests a new imaging method called qDSA that measures blood flow in real time during liver embolization, a procedure that blocks blood supply to tumors. Up to 20 participants will have qDSA and ultrasound images taken before, during, and after the procedure. The goal is…

This study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…

This study tests whether adding a technique called vascular deformation mapping (VDM) to standard CT scans can better predict liver failure after major liver surgery. Researchers will analyze routine preoperative CT images from over 1,000 adults undergoing removal of at least thr…

This study is building a prediction model to estimate the risk of heart injury after major liver surgery. Researchers will track 1800 patients undergoing hepatobiliary surgery and analyze factors like surgical technique and routine blood tests. The goal is to create a tool that h…

This study looks at whether measuring a substance called FMN in the fluid used to preserve donated livers can predict how well the liver will work after transplant. Researchers will collect samples from 850 liver transplant patients at multiple hospitals. The goal is to see if FM…

This study looks at images from 50 liver cancer patients who received a special dye (contrast agent) during a procedure before radiation therapy. Researchers want to see if a software program (KIM) can detect that dye in the images to better track the tumor during treatment. The …

This study aims to understand how liver diseases like fatty liver, hepatitis B, fibrosis, and cirrhosis develop by analyzing individual liver cells and their spatial organization. Researchers will collect blood and discarded liver tissue from 240 patients undergoing surgery or bi…

This study looks at two types of surgery for pancreatic and liver tumors: open surgery and minimally invasive surgery. Researchers want to see which one leads to better survival, shorter hospital stays, fewer complications, and lower costs. The study will review records of 431 pa…

This study is testing whether a camera can accurately measure heart rate, blood pressure, and oxygen levels by recording a patient's face during surgery. The goal is to replace some of the sticky sensors and cuffs that touch the skin, which can cause infections or injuries in fra…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This observational study follows 2000 adults with liver tumors who need surgery but have too little healthy liver left. Doctors use various techniques to make the liver grow before surgery. The study simply watches what happens in real practice—it does not test any new drug or tr…

This study looks at why the size of the treated area after microwave ablation for liver tumors can differ from what doctors expect. Researchers will review medical records of 90 adults to see how factors like liver health, tumor location, and prior treatments affect results. The …

This observational study is looking at whether certain substances in the blood can help predict and monitor how liver cancer responds to a treatment called TACE. Researchers will collect blood samples from 15 adult patients before and after TACE and compare them with standard ima…

This study looks at 100 adults having liver tumor treatment with a special breathing method called jet ventilation. Normally, carbon dioxide is measured in exhaled air, but that doesn't work here. Researchers will compare a skin sensor to a standard blood test to see if they give…