Leiomyoma

This study compares two surgical approaches for laparoscopic hysterectomy in women with benign or premalignant uterine conditions. One method uses a single incision through the belly button, while the other uses three to four small abdominal cuts. The goal is to see which techniq…

This study compares four surgical techniques to temporarily block blood flow to the uterus during laparoscopic fibroid removal. The goal is to see which method best reduces blood loss and protects ovarian function. Sixty women with uterine fibroids will be randomly assigned to on…

This study tested whether a daily combination pill (relugolix, estradiol, and norethindrone acetate) can prevent pregnancy in women aged 18 to 50 who have uterine fibroids or endometriosis. Over 1,100 women took the pill for up to a year, and researchers counted how many became p…

This study compared two treatments for symptomatic uterine fibroids—surgery (myomectomy) and a minimally invasive procedure (uterine artery embolization)—to see which one better helps women get pregnant and have a live birth. It included 9 women aged 18 to 43 with fibroids larger…

This study looked at 114 women with symptomatic uterine fibroids who wanted to keep their uterus. It compared the costs and short-term safety of three procedures: radiofrequency ablation (Acessa), myomectomy (surgical removal of fibroids), and uterine artery embolization (blockin…

This study followed over 1,500 women with moderate to severe uterine fibroids who were taking Esmya (ulipristal acetate) long-term. Researchers tracked side effects, especially those affecting the uterus, and how doctors prescribed the drug in everyday practice. The goal was to b…

This study tests whether a 5-minute educational video about uterine fibroids and their treatments can help patients feel less conflicted when deciding on a treatment plan. About 154 women with fibroids will be randomly assigned to watch the video before their appointment or recei…

This study tested a 3-month treatment with a combination of vitamin D, green tea extract (EGCG), vitamin B6, and D-Chiro-inositol in 108 women with uterine fibroids who were planning surgery. The goal was to see if the supplement could ease symptoms and possibly help some women a…

This study tested whether a nerve block (stellate ganglion block) combined with standard anesthesia could help women with uterine fibroids sleep better and feel less anxious after laparoscopic surgery. 233 women aged 35-55 took part. Results aim to show if this approach reduces s…

This study tested whether giving an anti-inflammatory steroid directly into the uterine arteries during a non-surgical fibroid treatment can lessen pain, nausea, vomiting, and tiredness afterward. Forty-two women with symptomatic fibroids took part. The goal was to see if this si…

This study tested whether injecting the numbing drug ropivacaine into the belly and around a nerve cluster before surgery can lower pain after laparoscopic fibroid removal. 207 women having fibroid surgery were randomly assigned to get either ropivacaine or a placebo. The main go…

This study tested whether a nerve block called the anterior quadratus lumborum block, given before surgery, can reduce pain and the need for opioids in women undergoing abdominal hysterectomy. 56 participants were randomly assigned to receive either the nerve block plus standard …

This pilot study tested whether taking a combination of EGCG (from green tea), vitamin D, and D-chiro-inositol for three months before hysteroscopic myomectomy improves surgical outcomes. 90 women with uterine fibroids were divided into two groups: one received the supplements be…

This study tested an oral drug called KLH-2109 in 89 premenopausal Japanese women with uterine fibroids who had heavy bleeding and pain. The goal was to see if the drug could reduce bleeding and pain better than a placebo. The trial was completed and may point to a new way to man…

This study tested two types of pain-relief injections (liposomal bupivacaine vs. standard bupivacaine) given during open fibroid surgery. 140 women participated to see which method reduced the need for opioid painkillers after the operation. The goal was to improve pain control a…

This study asks over 1,600 African American women aged 23-35 about their experiences during the COVID-19 pandemic. Participants fill out a short online or paper survey covering infection, vaccination, childcare, job loss, and emotional stress. The goal is to understand how the pa…

This study looks at how often women develop intrauterine adhesions (scar tissue inside the uterus) after having fibroids removed through laparoscopic or open surgery. Researchers will check for adhesions using a small camera inserted into the uterus three months after surgery. Th…

This study looked at whether measuring the stiffness of uterine fibroids can help predict how well they respond to a non-invasive treatment called MR-HIFU. Forty women with symptomatic fibroids were enrolled. The goal was to improve patient selection so that only those likely to …

This study looked at 40 women with symptomatic uterine fibroids to understand why MR-guided focused ultrasound (HIFU) works better for some than others. Researchers used MRI and contrast-enhanced ultrasound to measure fibroid blood flow, stiffness, and other features before treat…

This study looked back at the medical records of 293 women who had surgery to remove uterine fibroids (myomectomy). The goal was to find out how often a hysterectomy (removal of the uterus) was needed during the procedure and what complications occurred within 30 days after surge…

This completed observational study looked at 150 women to see how different types of fibroid removal surgery (hysteroscopic, laparoscopic, or laparotomic) affect pregnancy outcomes. It compared women who had surgery with those who did not, and also looked at whether surgery durin…

This study looked at 183 women with menstrual pain to understand why it happens and how naproxen (a common painkiller) relieves it. Using MRI scans, researchers measured uterine activity, blood flow, and oxygen levels before and after taking naproxen or a placebo. The goal is to …

This study looked at how the location of uterine fibroids affects blood flow in the uterine artery. Researchers used ultrasound to measure blood flow in 185 women with fibroids and compared results based on fibroid location. They found that fibroids located within the uterine mus…

This completed phase 1 study tested how SHR7280, a drug being developed for endometriosis and uterine fibroids, affects the way the body processes six other common drugs. Twenty healthy men took SHR7280 along with midazolam, warfarin, omeprazole, digoxin, and rosuvastatin to see …

This completed registry study collected real-world data on 99 patients receiving HydroPearl microspheres to block blood flow to conditions like uterine fibroids, arteriovenous malformations, hypervascular tumors, and benign prostatic hyperplasia. The procedure was done through th…