Large artery stroke

This study is testing whether placing stroke patients in a head-down position (Trendelenburg) before a clot-removal procedure can improve their recovery. Researchers will enroll 210 adults with a severe stroke caused by a large blocked artery. The goal is to see if this simple po…

This study tests whether raising carbon dioxide levels slightly during general anesthesia can improve blood flow to the brain before clot removal in stroke patients. Fifty adults with large-vessel stroke will be randomly assigned to either normal or moderately high carbon dioxide…

This study tests whether giving a strong cholesterol-lowering drug (PCSK9 inhibitor) before emergency stroke treatment helps people recover better. About 652 adults with a major stroke will be randomly assigned to receive either the intensive drug or standard care. The main goal …

This study tests whether removing a blood clot from the brain up to 72 hours after a stroke can help patients recover better than standard care. About 336 adults with severe strokes due to a large vessel blockage will be randomly assigned to get the clot removal procedure or usua…

This study compares two ways to remove blood clots from the brain during a stroke. About 500 adults who have a stroke from a large blocked artery will be randomly assigned to one of two standard techniques: a cyclic 'plunger' method or a steady suction method. The goal is to see …

This trial investigates whether giving a low dose of the clot-busting drug alteplase directly into the brain artery, right after successful mechanical clot removal, can improve recovery in people with a severe stroke caused by a large vessel blockage. About 416 adults who have ha…

This study looks at whether giving a clot-dissolving drug called Tenecteplase to stroke patients before they are moved to a hospital that can perform a clot-removal procedure improves their recovery. The trial involves 572 adults who had a stroke caused by a large blockage in the…

This study tests whether giving the clot-busting drug tenecteplase directly into the brain artery after standard clot removal can improve blood flow in tiny vessels. About 20 adults who had a major stroke from a large clot will receive a single dose of the drug through a catheter…

This study looks at whether successfully restoring blood flow in the brain using the Tigertriever device, a tool that removes clots during a stroke, may also help protect cognitive abilities like memory and attention. Researchers will follow 424 adults aged 18 to 75 who had a lar…

This study tests whether removing a blood clot from the brain (endovascular thrombectomy) plus standard medical care helps people who had a severe stroke 24 to 72 hours earlier. About 408 adults aged 18-85 with large-vessel blockage will be randomly assigned to get the procedure …

This study tests a new device called the RapidPulse Aspiration System, which uses precisely timed suction to remove blood clots from brain arteries in people having a severe stroke. The trial will enroll 170 adults aged 18 to 80 who can be treated within 8 hours of stroke symptom…

This study tests whether the drug sivelestat sodium, given alongside standard clot-removal surgery, can help people recover better after a major stroke. The trial will include 868 adults aged 18-80 with large-vessel blockage in the front part of the brain. The goal is to see if t…

This Phase 3 trial tests whether the drug tirofiban can help people who have had a stroke but missed the usual treatment window (more than 24 hours after symptoms start). The study uses a special MRI scan to select patients whose stroke is caused by a specific type of artery bloc…

This study tests whether giving hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) soon after emergency clot removal can improve recovery in people with severe stroke. Researchers plan to enroll 420 adults aged 18–80 who had a large-vessel blockage stroke …

This study looks at how well and how safely the Tigertriever device works to remove blood clots from large brain vessels in people having an ischemic stroke. About 150 adults will be treated within 8 hours of their first symptoms. The goal is to restore blood flow and improve rec…

This study looks at whether a procedure to remove a blood clot from the brain (endovascular therapy) can help people who had a mild stroke but then got worse because of a large blockage. The treatment is given more than 24 hours after the stroke started. About 272 adults with mil…

This study tests if briefly stopping and restarting blood flow in the neck after a stroke procedure can help the brain heal better. About 120 adults who had a major stroke and received emergency treatment to reopen a blocked artery will be randomly assigned to get this extra ther…

This study looks at whether adding evolocumab (a powerful cholesterol-lowering drug) to standard statin therapy helps people recover better after a stroke caused by hardening of the large arteries. Researchers will follow 1000 adults aged 18-80 for 90 days, comparing those who ge…

This study tests whether a newer clot-dissolving drug (tenecteplase) works better than the standard drug (alteplase) when given before a mechanical procedure to remove a large blood clot from the brain. About 850 adults who have had a severe stroke within the last 4.5 hours will …

This study tests whether giving the steroid methylprednisolone right after a stroke clot removal procedure can help patients recover better. About 210 adults who had a major stroke from a blocked artery in the brain will be randomly assigned to receive either the steroid or a pla…

This study looks at giving a second dose of the clot-busting drug tenecteplase to people having a stroke caused by a medium or large blocked artery. Participants must receive the first dose within 4.5 hours of symptoms and show little improvement after one hour. The goal is to se…

This study tests whether adding the drug cilostazol to the usual two blood thinners (aspirin and clopidogrel) can better prevent early stroke recurrence in people who had a stroke caused by narrowed arteries in the brain or neck. About 2,340 adults will be enrolled within 72 hour…

This study tests whether taking stroke patients straight to the angiography suite for clot removal, instead of first evaluating them in the emergency department, leads to better recovery. About 2,000 adults with severe stroke symptoms within 7 hours will be randomly assigned to o…

This study tests a special catheter designed to help remove large blood clots in the brain during a stroke. About 327 adults aged 22 to 85 who have a disabling stroke will be treated within 16 hours of symptoms. The goal is to see if the device safely restores blood flow in one p…

This study tests whether giving the blood-thinning drug tirofiban before a clot-removal procedure helps people recover better after a stroke caused by a blocked artery. About 870 adults with a large-vessel stroke will receive either tirofiban or a placebo before the procedure. Th…

This study tests whether a noninvasive arm cuff therapy, called remote ischemic conditioning, can improve recovery in people who have had a major stroke and undergone a clot-removal procedure. The therapy involves briefly inflating and deflating a cuff on the upper arm to protect…

This study is for people having a stroke caused by a blocked artery in the brain. It compares different methods of removing the clot (thrombectomy) to find which works best. About 1600 adults will take part, and the goal is to reduce long-term disability.

This study tests whether adding the drug tirofiban after a standard clot-removal procedure helps people recover better from a severe stroke caused by a blocked artery. About 716 adults will receive either tirofiban or a placebo right after the procedure. The main goal is to see i…

This study tests whether giving the steroid methylprednisolone right after a stroke clot removal procedure can help patients recover better. About 1060 adults who had a large-vessel stroke will receive either the drug or a placebo. The goal is to see if the drug reduces disabilit…

This study compares two antiplatelet drug combinations—ticagrelor plus aspirin versus cilostazol plus aspirin—given within 24 hours of a minor stroke or TIA. The goal is to see which combination better prevents new strokes over 90 days while keeping bleeding complications low. Ab…

This study tests a new device called the CONDA stent retriever, which is used to remove blood clots from the brain in people having a stroke. About 50 patients will be treated within 24 hours of their symptoms starting. The goal is to see if the device is safe and works well at r…

This phase 3 trial compares atorvastatin versus rosuvastatin, both given with clopidogrel, in 600 adults who had a first large-vessel ischemic stroke. The goal is to see which combination better prevents new strokes within 90 days. Participants receive either 40 mg atorvastatin o…

This phase 3 trial compares two anti-clotting drug combinations—aspirin plus ticagrelor versus aspirin plus clopidogrel—in 900 adults who recently had a minor stroke or transient ischemic attack (TIA) caused by a large artery blockage. Participants receive the drugs within 24 hou…

This study looks at whether lying flat (0 degrees) or with the head raised (30 degrees or more) after a stroke clot removal procedure helps people recover better. About 2240 adults who had a stroke from a large blood vessel blockage will be randomly assigned to one of the two hea…

Researchers are studying blood proteins in people who have a severe ischemic stroke caused by a blocked artery in the front of the brain. All 800 participants receive endovascular treatment, a procedure that threads a catheter through blood vessels to remove the clot. The team me…

This study is testing whether a gentle electrical stimulation of a nerve in the ear (the vagus nerve) can reduce brain injury and inflammation after a severe stroke. Researchers will measure brain damage markers in the blood of 65 participants over a week. The goal is to see if t…

This study is for people who have had a very large stroke caused by a blocked artery in the brain. Doctors want to see if a procedure to remove the clot (called thrombectomy) can help them recover better. The study will track 1000 patients for 90 days to measure their level of di…

This study tests whether a special blood pressure cuff (Doctormate) can be used during helicopter transport to protect brain tissue in people having a severe stroke. Ten patients with large vessel occlusion will receive remote limb ischemic conditioning (RLIC) while being flown t…