Steroid shot after stroke may boost recovery, new trial hopes

NCT ID NCT07516522

Disease control Sponsor: Tang-Du Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving the steroid methylprednisolone right after a stroke clot removal procedure can help patients recover better. About 210 adults who had a major stroke from a blocked artery in the brain will be randomly assigned to receive either the steroid or a placebo. The main goals are to see if the treatment reduces bleeding in the brain and lowers the risk of death.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: methylprednisolone (a steroid anti-inflammatory drug)
What this could lead to: If it works, this could become a standard add-on treatment to improve recovery and reduce complications after stroke clot removal.
What could go wrong: This is a Phase 2 trial with 210 participants, so results are still early. Steroids can increase infection risk, and the benefit may not be large enough to change practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 210 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-80 years old; * The time from onset to randomization was within 24 hours; * Large vessel occlusive stroke in the anterior circulation confirmed by CTA/MRA/DSA (Including intracranial segment of internal carotid artery, M1 or M2 segment of middle cerebral artery) and the vessel responsible for the signs and symptoms of acute ischemic stroke; * NIHSS score \>= 6 points * Alberta Stroke Program Early Diagnosis (ASPECTS) score of NCCT \>=3; * Successful endovascular thrombectomy (eTICI 2b50-3) * Written informed consent signed by patients or their family members Exclusion Criteria: * Intracranial hemorrhage confirmed by computed tomography (CT) or magnetic resonance imaging (MRI); * Prestroke mRS score \>= 2 * pregnant or lactating patients * Allergy to iodinated contrast media, or methylprednisolone sodium succinate * Participating in other clinical research; * Inherited/acquired hemorrhagic diathesis (coagulation factor deficiency) or oral anticoagulation with international normalized ratio (INR) \>1.7 * History of major bleeding within the past 1 month (gastrointestinal/genitourinary hemorrhage) * Chronic hemodialysis and severe renal insufficiency (glomerular filtration rate \< 30ml/min/1.73m\^2 or serum creatinine \> 220μmol/L (2.5mg/dl)); * Terminal illness with life expectancy \<6 months; * Blood glucose \< 2.8mmol/L (50mg/dl) or \> 22.2mmol/L (400mg/dl); * Intracranial aneurysm, arteriovenous malformation, or space-occupying brain tumor with mass effect on imaging * Active systemic infectious disease * Anticipated inability to complete follow-up * Intraoperative DSA showed vascular perforation, dissection, and contrast extravasation; * Puncture to recanalization was more than 90 minutes; * Total thrombectomy passes \>3

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Conditions

The condition(s) this trial relates to.

cerebral artery occlusion ischemic stroke large artery stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ischemia stroke Large vessel occlusion Thrombectomy

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Steroid shot after stroke may boost recovery, new trial hopes

What the study statuses mean