Ischemia reperfusion injury

This trial compares two common diuretics—furosemide and mannitol—given during kidney transplant surgery to see which better prevents delayed graft function, a condition where the new kidney does not work right away and requires dialysis. The study enrolls adults receiving a decea…

This study tests a technique called remote ischemic preconditioning (RIPC) during emergency surgery for a life-threatening aortic tear. RIPC involves briefly inflating a blood pressure cuff on the arm and thigh to temporarily restrict blood flow, which may help protect the heart,…

This study tests a medicine called Xolatryp in adults who have had a severe heart attack (STEMI) and are getting a procedure to open blocked arteries. Participants receive either a single 6-hour infusion of Xolatryp or a placebo, and their heart health is monitored for 30 days. T…

This study tests a new approach for liver transplantation: after keeping the donor liver warm on a machine, doctors skip the usual cold flush before implanting it. Instead, they use a room-temperature albumin rinse. The goal is to see if avoiding sudden temperature changes reduce…

This trial investigates whether ursodeoxycholic acid (UDCA), a bile acid medication, can protect kidney function in adults undergoing partial nephrectomy for kidney cancer. During surgery, blood flow to the kidney is temporarily stopped, which can cause injury. Participants take …

This study tests whether a drug called treprostinil can help prevent injury to a new kidney during transplant surgery. About 20 adults receiving a deceased donor kidney will get the drug through an IV for two days, starting just before surgery. The goal is to see if it improves b…

This study tests whether storing donated kidneys at 10°C (instead of the usual 4°C on ice) helps them work better after transplant. About 30 adults waiting for a kidney transplant will take part. Researchers will measure kidney function and check for early injury using urine test…

This study tests a special silicone jacket that wraps around a donor kidney during transplant surgery to keep it warm. The goal is to see if the jacket is safe to use in different types of kidney transplants. Twenty adult recipients will be enrolled, and the study will track any …

This study tests a new approach for children on ECMO life support who have heart damage. Doctors will take a small sample of the child's own mitochondria (the energy parts of cells) and inject them directly into the heart muscle. The goal is to see if this is safe and helps the h…

This study tests whether a single injection of morphine around certain neck nerves can reduce heart muscle damage after a heart attack. About 166 adults who have had a severe heart attack and undergone artery-opening treatment will receive either morphine or a saltwater placebo. …

This study tests a new way to reduce heart damage after a severe heart attack (STEMI). Doctors will cool the heart's arteries during the standard procedure to open blocked vessels. The goal is to see if this cooling prevents further injury and improves heart function. The trial i…

This study tests a drug called BX-001N to see if it can prevent acute kidney injury in people having heart surgery. About 40 adults will receive either a low dose, high dose, or a placebo. The goal is to see if the drug can keep kidneys working well after surgery.

This study uses special MRI scans to look at how well a donated kidney works in the recipient and how the donor's remaining kidney adapts over one year. It includes 80 adults (donors and recipients) and aims to help doctors choose the best kidneys for transplant. The goal is to b…

This study looks at whether having obstructive sleep apnea (OSA) might help protect the body from damage during surgery to fix a large blood vessel (aortic aneurysm). The idea is that the short, repeated drops in oxygen from sleep apnea might train the body to handle the stress o…

This observational study follows 30 women undergoing DIEP flap breast reconstruction after mastectomy. Researchers will measure inflammation and oxidative stress markers in blood samples taken before and after surgery. The goal is to understand how the body responds to the tempor…