Head and neck carcinoma

Researchers are testing an experimental antibody called ONC-392 in people with advanced solid tumors, including non-small cell lung cancer and melanoma. The trial gives ONC-392 alone or with pembrolizumab, an approved immunotherapy, to see what doses are safe and how the body pro…

This phase II trial compares two types of radiation for people whose head and neck cancer has come back and cannot be removed with surgery. One method delivers high-dose radiation in fewer sessions, while the other uses standard daily doses over several weeks. The study aims to s…

This early-phase trial tests an experimental drug called BAY 1895344 combined with standard chemotherapy (cisplatin, with or without gemcitabine) in people with advanced solid tumors, especially urothelial cancer. The goal is to find the best dose and see how safe the combination…

This study tests whether a pea protein nutritional drink can reduce the need for feeding tubes in people with head and neck cancer undergoing chemoradiation. About 57 adults with locally advanced cancer will drink the supplement as a meal replacement. The goal is to see if it hel…

This study is testing whether a precise form of radiation called proton therapy can control head and neck cancer after surgery as well as standard X-ray radiation, but with fewer side effects. About 174 adults with newly diagnosed head and neck cancer will receive either proton t…

This phase 1 study tests whether adding a highly targeted, high-dose radiation boost (stereotactic body radiotherapy, or SBRT) to standard radiation and chemotherapy can safely treat head and neck cancer that has come back or spread. The trial includes two groups: patients whose …

This early-phase trial tests several new drug combinations in people with advanced solid tumors (like stomach, ovarian, or liver cancer) that have spread and stopped responding to standard treatments. The goal is to find the safest dose and see if the drugs can help control the c…

This early-phase trial tests the safety of combining two cancer drugs, nivolumab and cabozantinib, in people with HIV who have advanced solid tumors. Only 8 participants were enrolled. The goal is to see if the combination is safe and can shrink or stabilize tumors.

This study tests whether combining two treatments—thermal ablation (using heat to destroy tumor cells) and stereotactic radiosurgery (precise, high-dose radiation)—can better control cancer that has spread to the spine and is pressing on the spinal cord. About 60 adults with vari…

This phase 2 trial tests whether adding ramucirumab to pembrolizumab (Keytruda) works better than pembrolizumab alone for people with PD-L1 positive head and neck cancer that has come back or spread. About 37 participants will receive either the combination or the single drug. Th…

This study tests two drugs, pembrolizumab and cabozantinib, in 36 people with head and neck cancer that has returned or spread and cannot be surgically removed. The goal is to see if the combination shrinks tumors and delays cancer growth. Participants receive both drugs intraven…

This early-stage trial tests a new drug called DECOY20, which is designed to wake up the immune system to fight cancer. It is being tested alone or with another drug (tislelizumab) in 120 adults with advanced solid tumors like liver, lung, or colorectal cancer. The main goals are…

This early-phase trial explores whether two experimental PET/CT tracers, 68Ga-FAPI-46 and 68Ga-PSMA-11, can accurately highlight various non-prostate cancers, including breast, lung, and pancreatic tumors. Participants scheduled for surgery will receive the tracers before their s…

This phase 1 trial is testing a new imaging tracer called 68Ga-FAPI-46 to see where it collects in normal and cancerous tissues. About 30 people with various solid tumors or blood cancers will receive the tracer and then undergo a PET/CT scan. The goal is to understand how the tr…

This study tests whether manual therapy—gentle massage and stretching of the neck, throat, jaw, and mouth—can improve swallowing and movement in head and neck cancer survivors who have long-term swallowing problems due to tissue scarring (fibrosis). About 24 survivors who finishe…

This pilot study looks at whether giving fluoride varnish during regular cancer checkups can help protect the teeth of head and neck cancer patients who have had radiation and lack easy access to a dentist. About 43 uninsured or underinsured adults will receive 4-5 fluoride treat…

This study compares two pain management approaches—neurofeedback (brain wave training) and a supportive care team—against standard care in 28 head and neck cancer patients at risk of misusing opioids. The goal is to see if these methods can lower pain and reduce the need for stro…

This small pilot study tests whether neurofeedback training can help reduce pain caused by radiation therapy in head and neck cancer patients. Participants learn to modify their own brain waves using EEG and computer software. The goal is to see if this technique can lower pain p…

This study looks at whether a partner-based (dyadic) yoga program can improve quality of life and reduce hospital visits for head and neck cancer patients undergoing chemoradiation, as well as their family caregivers. About 415 patient-caregiver pairs are taking part. The yoga se…

This phase II trial tests whether Soylent, a liquid meal replacement, can help head and neck cancer patients avoid needing a feeding tube during chemoradiotherapy. About 60 patients with locally advanced cancer will drink Soylent alongside their treatment. The goal is to see if t…

This study tracks 125 head and neck cancer patients after surgery to see how many end up using opioid painkillers long-term. Researchers will also look at factors like symptom burden and risk of opioid misuse. The goal is to better understand who is most at risk and why.

This phase II trial, called MATCH, is testing whether treating cancer based on the genetic makeup of a patient's tumor works better than standard treatments. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to prior therapy are …

This study gathers medical information from 450 head and neck cancer patients who received or will receive proton therapy. Researchers will analyze outcomes and side effects to help doctors improve treatment for future patients. The study does not test a new treatment but collect…

This study checks if a special scale can accurately measure muscle and fat in 50 head and neck cancer patients getting radiation therapy. The goal is to see if the scale can spot muscle loss early, helping doctors decide when to add nutrition support or a feeding tube. Participan…

This study examines DNA from over 21,000 cancer patients in New York to find gene changes linked to several cancers, including breast, colon, and lung. Researchers will compare these genes to those from healthy people to spot differences. The goal is to generate ideas for future …