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Can a simple fluoride treatment save teeth after cancer radiation?

NCT ID NCT07556367

Symptom relief Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study looks at whether giving fluoride varnish during regular cancer checkups can help protect the teeth of head and neck cancer patients who have had radiation and lack easy access to a dentist. About 43 uninsured or underinsured adults will receive 4-5 fluoride treatments, complete surveys, and provide saliva samples. The goal is to see if this approach is practical and might improve dental health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fluoride varnish treatment
What this could lead to
If successful, this could show that providing fluoride varnish during routine cancer visits is a practical way to improve dental health in underserved patients.
What could go wrong
This is a small pilot study with only 43 participants, so results may not apply broadly. It focuses on feasibility, not on proving the varnish prevents cavities.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

43 people

The number who actually took part.

Started

Oct 2024

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. \>18 years old who are uninsured or underinsured (MediCal, Healthy SF) or have full coverage. 2. Patients who have received immunotherapy or enhanced chemotherapy regimens. 3. Patients or health and dental care providers who are able to provide their own informed written consent. Exclusion Criteria: 1. \>18 years old. 2. Patients, caregivers, health and dental care providers who are able to provide their own informed written consent.

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Conditions

The condition(s) this trial relates to.

head and neck cancer head and neck carcinoma head and neck neoplasm Head and Neck Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Head and neck cancer Head and neck carcinoma Head and neck neoplasms

Contacts and locations

Locations

  • Zuckerberg San Francisco General Hospital (ZSFG)

    San Francisco, California, 94110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.