Gout

This study tests an experimental drug called SSGJ-613, a lab-made antibody, to prevent sudden gout attacks in people who are starting medication to lower uric acid. About 200 adults with frequent gout flares will receive either SSGJ-613 injections or standard colchicine pills for…

This study compares starting dotinurad, a urate-lowering drug, during an acute gout flare versus waiting until the flare resolves. About 142 adults with gout will be randomly assigned to one of two timing schedules. Researchers will measure how quickly the flare resolves and whet…

This study will follow 264 adults with frequent gout flares to see how often attacks return within 24 weeks after starting firsekibart. Researchers will also track side effects and how quickly flares resolve. The goal is to understand if this medication helps control gout in ever…

This study looks at whether taking Firsekibart regularly (every 4 weeks) is better than using it only when a gout flare starts. It involves 118 adults who had no flares during 24 weeks of initial treatment. The goal is to see which approach prevents more gout attacks over the nex…

This study tests whether a probiotic-uricase supplement can safely lower uric acid levels in people with hyperuricemia. 45 adults will take the supplement for 2 weeks, and researchers will track changes in uric acid, gut bacteria, and related metabolites. The goal is to see if th…

This Phase 2 trial tests BR2251, a new daily tablet, in 160 adults with gout and high uric acid. Participants receive one of three doses of BR2251 or the standard drug febuxostat for 12 weeks. The goal is to see which dose best lowers uric acid levels and reduces gout flare-ups.

This study tests whether having a pharmacist guide gout medication adjustments through regular telehealth visits can improve outcomes compared to usual care. It will enroll 310 veterans at five VA medical centers and follow them for up to two years. The goal is to lower uric acid…

This study tests whether adding the weight-loss drug orlistat to standard gout treatment helps obese patients lower uric acid levels and reduce gout attacks. 120 adults with gout and obesity will take either orlistat or a placebo for 24 weeks, along with diet and exercise advice.…

This study will compare cycling and jogging in 90 adults with gout who have had ankle attacks. Participants will continue standard urate-lowering medication and exercise moderately for 45-60 minutes per session. Researchers will track gout flare frequency, blood uric acid levels,…

Rheumatoid arthritis and gout can look alike, making them hard to tell apart early. This study will use ultrasound to see if it can reliably distinguish between the two conditions. Researchers will examine 100 adults with suspected or confirmed arthritis, scoring joint inflammati…

This study tests whether a genetic test can prevent rare but severe skin reactions caused by the common gout drug allopurinol. About 228 Vietnamese adults with gout will either get the test before treatment or receive standard care. Those with a high-risk gene will take a differe…

Researchers are testing whether mazdutide, a weekly injected drug, reduces the number of gout flares in adults who have both obesity and gout. The study enrolls 30 people aged 18 to 65 with a BMI of at least 30 and at least two gout flares in the past six months. Everyone receive…

This study looks at whether the urate crystals that cause gout flare-ups in the feet are linked to plaque buildup in the heart's arteries. Researchers will use two types of CT scans to measure urate deposits in the feet and plaque in the coronary arteries of 200 adults with gout …

This early-stage study looks at how a single dose of a probiotic supplement changes gene activity and sugar patterns in the small intestine of 8 healthy adults. Participants will take the probiotic alone, with fiber, or a placebo, then have a small tissue sample taken the next mo…