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Gut bacteria supplement could tame high uric acid
NCT ID NCT07613164
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a probiotic-uricase supplement can safely lower uric acid levels in people with hyperuricemia. 45 adults will take the supplement for 2 weeks, and researchers will track changes in uric acid, gut bacteria, and related metabolites. The goal is to see if this oral supplement could be a new way to manage high uric acid and gout.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Probiotic-uricase complex preparation (dietary supplement)
- What this could lead to
- If it works, this could point toward a simple, oral supplement to help manage high uric acid and reduce gout risk.
- What could go wrong
- This is a very small, early exploratory study with only 45 people. It is not yet recruiting, and results may not lead to a proven treatment. The supplement is taken for just 2 weeks, so long-term effects are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 45 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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May 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18-60 years. * Men with serum uric acid levels \> 420 μmol/L on 2 separate occasions (not on the same day), women with serum uric acid levels \> 360 μmol/L on 2 separate occasions (not on the same day). * Participants must sign an informed consent form and be able to cooperate with sample collection. Exclusion Criteria: * A history of or current presence of a clearly defined organic intestinal disease, such as intestinal malignant tumor, inflammatory bowel disease, intestinal obstruction, or intestinal polyp. * Concurrent severe systemic diseases, including severe cardiovascular or cerebrovascular disease (eg., myocardial infarction within the past 6 months, NYHA Class III-IV heart failure, or uncontrolled hypertension), significant liver function abnormalities (ALT or AST \> 2 times the upper limit of normal), moderate-to-severe renal insufficiency (eGFR \< 45 mL/min/1.73 m²) or uncontrolled diabetes (HbA1c ≥ 9%). * Use of antibiotic, probiotic preparation, or other drugs that may significantly alter the gut microbiota within 4 weeks prior to enrollment, or those requiring continued use of such drugs during the study. * Women who are pregnant or lactating, or who plan to become pregnant during the study. * Participants with severe tophus or gouty nephropathy. * Participants who have participated in another clinical trial within 3 months prior to enrollment. * Participants with other health problems that render them unsuitable for enrollment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
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