Gastroesophageal reflux disease

This trial tests whether a small implanted device that electrically stimulates the lower esophageal sphincter can reduce acid reflux in people with GERD. Participants receive either active stimulation or a sham (inactive) device for six months, then all receive stimulation. The s…

This study tracked 350 people with GERD who received a device that electrically stimulates the muscle that keeps stomach acid from rising. The goal was to see how safe the device is over 5 years and whether it improves symptoms and quality of life. The registry included both new …

This study aimed to compare a standard sleeve gastrectomy (removing part of the stomach) with a modified version called N-Sleeve, which adds a wrap around the top of the stomach to prevent acid reflux. The trial was designed for people with severe obesity and GERD, but only 2 pat…

This study investigates whether osteopathic manipulative treatment (OMT) — a form of hands-on manual therapy — can reduce symptoms like heartburn and regurgitation in people with gastro-oesophageal reflux disease (GERD). The trial includes 26 adults who have had symptoms for at l…

This study looked at whether using a CPAP machine at night could reduce abnormal acid reflux and lung inflammation in people with idiopathic pulmonary fibrosis (IPF) who also have sleep apnea. Only 7 people enrolled before the study was terminated early. The goal was to measure c…

This registry tracked 336 adults who had surgery for a large hiatal hernia (over 3 cm) at least two years earlier. Some received a LINX magnetic implant to strengthen the valve between the stomach and esophagus, while others had a fundoplication (wrapping the stomach around the e…