Epilepsy syndrome

This study looks at the best way to switch children with Dravet or Lennox-Gastaut syndrome from artisanal (non-pharmaceutical) cannabidiol to Epidiolex, an FDA-approved CBD medication. About 25 children aged 2 to 18 will gradually increase their Epidiolex dose while reducing thei…

This trial tests whether an experimental drug called JZP926 can safely reduce the number of days people aged 10 and older experience myoclonic seizures—brief, shock-like jerks—due to juvenile myoclonic epilepsy. Participants are randomly assigned to receive either JZP926 or a pla…

This trial tests whether a gradual dosing schedule of cannabidiol oral solution (CBD-OS) can help reduce seizures in adults with Lennox-Gastaut syndrome, a severe form of epilepsy. Participants will take CBD oil alongside their usual seizure medications. The study measures how ma…

This Phase 3 trial tests two existing anti-inflammatory drugs, anakinra and tocilizumab, in 438 patients with NORSE, a rare condition causing continuous seizures that don't respond to standard treatments. Patients are randomly assigned to one drug within 7 days of illness, and re…

This study tests whether the drug ganaxolone can reduce seizures in children aged 6 months to 2 years with CDKL5 deficiency disorder, a rare genetic condition causing hard-to-control seizures. Twenty children will receive either ganaxolone or a placebo alongside their usual seizu…

This early-stage trial tests a new cell therapy called UX-GIP001 for adults with drug-resistant temporal lobe epilepsy. The treatment involves injecting special brain cells into the seizure area to calm overactive nerves. Only 12 people will take part, and the main goal is to che…

This early study will test a new way to use deep brain stimulation (DBS) in 4 adults with Lennox-Gastaut syndrome, a severe form of epilepsy. The device will automatically adjust stimulation based on whether the person is awake or asleep. Researchers want to see if this personali…

This study tests whether lowering body temperature to about 91°F for 24 hours improves brain recovery in adults with severe seizures that don't stop with standard medicines. About 466 people on breathing machines will be randomly assigned to cooling or normal temperature care. Th…

This study tests whether giving the drug ketamine earlier, along with midazolam, can stop prolonged seizures faster in adults. Researchers will compare early versus late ketamine timing in 50 patients with refractory status epilepticus. The goal is to see if earlier use shortens …

This study tests whether combining standard MRI with two advanced techniques—MRI volumetry and diffusion tensor imaging—can more accurately identify the seizure-causing brain area in people with temporal lobe epilepsy. Researchers will compare these imaging results with clinical …

This study tests whether listening to specific music pieces every morning and night for six months can improve sleep and health in children aged 1.5 to 9 years with epilepsy, as well as their parents. Participants are randomly assigned to hear either a specially designed music tr…

This study tests whether taking a daily hot bath (40-42°C for 20 minutes) at home can reduce epileptic seizures in children with CDKL5 deficiency disorder. The trial will include 34 children aged 6 months to 14 years whose seizures are not controlled by medication. Researchers wi…

This study tests whether a non-invasive brain stimulation technique called temporal interference (TI) can reduce abnormal brain activity and improve sleep in adults with drug-resistant temporal lobe epilepsy. Twenty participants will stay in a sleep lab for six nights, receiving …

This study tests a new, non-invasive brain stimulation method called temporal interference (TI) for people with drug-resistant temporal lobe epilepsy. 30 adults will receive 5 days of TI stimulation targeting the hippocampus. The goal is to see if this reduces seizure frequency o…

This study tests whether high doses of melatonin, a natural sleep hormone, can safely reduce abnormal brain activity in children with DEE-SWAS, a rare epilepsy that causes skill loss. Only 3 children will participate, and researchers will monitor side effects and changes in brain…

Researchers are testing whether blood samples can reveal brain damage and inflammation in people with Dravet syndrome, a severe form of epilepsy that also affects development. The study compares blood markers from 60 people with Dravet syndrome to 30 healthy controls, and follows…

This study will check if two common brain monitors used during anesthesia (BIS and Sedline) give accurate readings in children with severe seizure disorders. Researchers will compare these monitors to a standard EEG in 40 children under 16. The goal is to make anesthesia safer fo…

This study tests a new DNA technology called long-read genome sequencing in 20 children with severe epilepsy whose standard genetic tests came back normal. The goal is to find hidden genetic causes that standard tests miss, which could lead to better treatments and genetic counse…

This study explores whether a special MRI technique called CEST can locate the brain area causing seizures in people with drug-resistant epilepsy. Researchers will scan 20 patients before surgery and compare the MRI results with standard methods. If it works, this could reduce th…

This study tests whether a wearable device that records brain waves, heart rate, and movement at home can help doctors better adjust the dose of the seizure drug fenfluramine for people with Dravet syndrome or Lennox-Gastaut syndrome. Twenty patients will wear the device for 3-7 …