Epilepsy syndrome
MONDO:0015650A syndrome that has a characteristic cluster of clinical features and/or lectroencephalographic (EEG) findings that reflect underlying epileptic activity. It is often associated with a range of other health issues, including cognitive impairment, intellectual disability, physical gross motor and fine motor delays, speech and language deficits, and impacts to other bodily functions and may be supported by specific etiological findings—such as structural, genetic, metabolic, immune, or infectious causes or have an unknown etiology.
Also known as: epileptic syndrome, syndromic epilepsy
186 clinical trials for this condition and its sub-types, 2 tagged with Epilepsy syndrome itself.
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Sub-types of Epilepsy syndrome
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Childhood-onset epilepsy syndrome 18 trials · 106 incl. sub-types
16 sub-types
- Familial partial epilepsy 0 trials · 39 incl. sub-types Sub-types →
- Childhood-onset epilepsy syndrome with developmental and/or epileptic encephalopathy 0 trials · 37 incl. sub-types Sub-types →
- New-onset refractory status epilepticus 8 trials
- Childhood-onset idiopathic generalized epilepsy syndrome 0 trials · 7 incl. sub-types Sub-types →
- Childhood-onset self-limited focal epilepsy syndrome 0 trials · 3 incl. sub-types Sub-types →
- Atypical childhood epilepsy with centrotemporal spikes 1 trial
- Rolandic epilepsy-speech dyspraxia syndrome 0 trials · 1 incl. sub-types Sub-types →
- Landau-Kleffner syndrome 0 trials
- Sunflower syndrome 0 trials
- Acute encephalopathy with biphasic seizures and late reduced diffusion 0 trials
- Childhood-onset genetic generalized epilepsy syndrome 0 trials Sub-types →
- Cryptogenic late-onset epileptic spasms 0 trials
- Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation 0 trials
- Perioral myoclonia with absences 0 trials
- Rolandic epilepsy-paroxysmal exercise-induced dystonia-writer's cramp syndrome 0 trials
- Self-limited childhood occipital epilepsy 0 trials Sub-types →
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Neonatal/infantile epilepsy syndrome 1 trial · 55 incl. sub-types
3 sub-types
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Variable age epilepsy syndrome 0 trials · 31 incl. sub-types
4 sub-types
- Variable-age onset idiopathic generalized epilepsy syndrome 0 trials · 17 incl. sub-types Sub-types →
- Variable-age epilepsy syndrome with developmental and/or epileptic encephalopathy or progressive neurological deterioration 0 trials · 14 incl. sub-types Sub-types →
- Variable-age onset combined generalized and focal epilepsy syndrome 0 trials Sub-types →
- Variable-age onset focal epilepsy syndrome 0 trials Sub-types →
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Myoclonic epilepsy 1 trial · 16 incl. sub-types
7 sub-types
- Progressive myoclonus epilepsy 5 trials · 12 incl. sub-types Sub-types →
- Juvenile myoclonic epilepsy 3 trials Sub-types →
- Epilepsy, familial adult myoclonic 0 trials Sub-types →
- Familial infantile myoclonic epilepsy 0 trials
- Myoclonic epilepsy in infancy 0 trials
- Myoclonic epilepsy in non-progressive encephalopathies 0 trials
- Myoclonic epilepsy, Hartung type 0 trials
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Infantile epilepsy syndrome 2 trials · 10 incl. sub-types
9 sub-types
- Undetermined early-onset epileptic encephalopathy 1 trial · 6 incl. sub-types Sub-types →
- Intellectual disability, autosomal dominant 5 2 trials
- Benign partial infantile seizures 0 trials Sub-types →
- Idiopathic hemiconvulsion-hemiplegia syndrome 0 trials
- Infant epilepsy with migrant focal crisis 0 trials
- Infantile spasms-broad thumbs syndrome 0 trials
- Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression 0 trials
- Myoclonic epilepsy in infancy 0 trials
- Progressive myoclonic epilepsy with dystonia 0 trials
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Neonatal epilepsy syndrome 1 trial · 7 incl. sub-types
6 sub-types
- Undetermined early-onset epileptic encephalopathy 1 trial · 6 incl. sub-types Sub-types →
- Benign idiopathic neonatal seizures 0 trials
- Benign neonatal seizures 0 trials Sub-types →
- Developmental and epileptic encephalopathy, 39 0 trials
- Malignant migrating partial seizures of infancy 0 trials Sub-types →
- Severe neonatal-onset encephalopathy with microcephaly 0 trials
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Benign focal seizures of adolescence 0 trials
Most studied deeper sub-types
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Seizure drug safety trial halted early for dravet and LGS patients
Disease control Stopped earlyThis study looked at the long-term safety of soticlestat when added to standard seizure medicines for people with Dravet syndrome or Lennox-Gastaut syndrome. It included 352 children and adults who had already been in earlier studies. The trial was terminated early, so results ar…
Phase 3 • Sponsor: Takeda • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Can a new drug tame seizures in two severe epilepsy syndromes?
Disease control Stopped earlyThis phase 3 trial tests whether soticlestat can reduce seizures in people with Dravet syndrome or Lennox-Gastaut syndrome who have already used fenfluramine. Participants take soticlestat as tablets or mini-tablets, and researchers measure changes in seizure frequency over the f…
Phase 3 • Sponsor: Takeda • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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New drug shows promise for Tough-to-Treat seizures in kids
Disease control Stopped earlyThis study looked at the long-term safety of soticlestat, an experimental drug, in children and adults with severe forms of epilepsy like Dravet syndrome and Lennox-Gastaut syndrome. Participants took soticlestat twice a day along with their usual seizure medicines. The study was…
Phase 2 • Sponsor: Takeda • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Promising seizure drug study halted early
Disease control Stopped earlyThis study looked at the long-term safety of the drug NBI-921352 for people with a rare genetic seizure disorder called SCN8A-DEE. It was an extension of an earlier study, and participants took the drug alongside their usual seizure medications. The study was stopped early and on…
Phase 2 • Sponsor: Neurocrine Biosciences • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Could a repurposed drug tame seizures in adult dravet patients?
Disease control Stopped earlyThis study tested the drug fenfluramine (FINTEPLA) in adults with Dravet syndrome whose seizures were not controlled by other medications. The trial was open-label and added fenfluramine to existing treatments. It aimed to see if the drug could reduce monthly seizures by at least…
Phase 3 • Sponsor: University Health Network, Toronto • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New drug aims to tame hard-to-control seizures in rare mitochondrial disorders
Disease control Stopped earlyThis study tested a drug called vatiquinone in 68 people with mitochondrial disease and epilepsy that doesn't respond to standard treatments. Participants were randomly assigned to receive either vatiquinone or a placebo for 24 weeks to see if the drug could reduce the number of …
Phase 2/3 • Sponsor: PTC Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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Epilepsy drug study halted early: BHV-7000 shows limited promise
Disease control Stopped earlyThis study tested whether BHV-7000, taken alongside other medications, could reduce generalized tonic-clonic seizures in people with idiopathic generalized epilepsy. The trial was terminated early and enrolled only 27 adults aged 18-75. The main goal was to see how long it took f…
Phase 2/3 • Sponsor: Biohaven Therapeutics Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Epilepsy drug study for kids halted early: what we know
Disease control Stopped earlyThis study looked at the long-term safety of a drug called NBI-827104 in children with a rare epilepsy that causes seizures during sleep. The trial was stopped early and only enrolled 19 children, so the results are limited. The main goal was to see how many children had serious …
Phase 2 • Sponsor: Neurocrine Biosciences • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Promising epilepsy drug trial halted early – what we know
Disease control Stopped earlyThis study tested an experimental drug called NBI-921352 in people aged 2 to 21 with a rare, severe form of epilepsy caused by a change in the SCN8A gene. The goal was to see if adding this drug to their current seizure medicines could reduce how often they had seizures. The tria…
Phase 2 • Sponsor: Neurocrine Biosciences • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Seizure drug study halted after just one patient
Disease control Stopped earlyThis study tested the drug perampanel in adults whose seizures did not stop with standard treatments. The goal was to see if it could safely stop seizures and reduce time in the hospital. Only one person enrolled before the study was ended early, so no clear conclusions can be dr…
Phase 4 • Sponsor: Wayne State University • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Dravet syndrome drug trial halted early: did lorcaserin help?
Disease control Stopped earlyThis study tested whether lorcaserin, when added to current medications, could reduce convulsive seizures in people with Dravet syndrome, a severe form of epilepsy. The trial planned to enroll about 22 participants aged 2 and older, but it was terminated early. The main goal was …
Phase 3 • Sponsor: Eisai Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Can a Two-Week hormone course stop epilepsy before it starts?
Prevention Stopped earlyThis trial tests whether giving a low dose of the hormone ACTH to infants with early warning signs on their brain wave test (EEG) can prevent West syndrome, a severe form of epilepsy. Infants between 2 and 12 months old who show a specific pre-seizure brain pattern are treated wi…
Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago • Aim: Prevention
Last updated Sep 11, 2026 00:00 UTC
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Nerve block or antidepressant? study tests two migraine treatments Head-to-Head
Symptom relief Stopped earlyThis study compares two treatments for transformed migraine (chronic daily headache): a sphenopalatine ganglion nerve block using lidocaine gel applied inside the nose, versus daily oral amitriptyline (Elavil), an antidepressant often used for migraine prevention. Ten adults aged…
Phase 4 • Sponsor: Rutgers, The State University of New Jersey • Aim: Symptom relief
Last updated Jun 27, 2026 14:03 UTC
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CBD study for baby seizures halted early
Symptom relief Stopped earlyThis study tested a cannabidiol (CBD) oral solution in children under 2 years old with tuberous sclerosis complex, Dravet syndrome, or Lennox-Gastaut syndrome who had uncontrolled seizures. The goal was to see if CBD is safe and can reduce seizures. However, the study was termina…
Phase 3 • Sponsor: Jazz Pharmaceuticals • Aim: Symptom relief
Last updated Jun 27, 2026 07:56 UTC
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New implant could track seizures for months
Knowledge-focused Stopped earlyThis study tested a small device implanted under the scalp to record brain waves (EEG) continuously for up to 12 weeks in people with epilepsy. The goal was to see if it could detect seizures better than standard short-term hospital monitoring and patient diaries. The trial invol…
Sponsor: UNEEG Medical A/S • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:35 UTC